Repaglinide and Clonidine Interaction
Drug interaction information between Repaglinide and Clonidine.
Repaglinide and Clonidine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Repaglinide and Clonidine. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Clonidine can hide the warning signs of low blood sugar and may also cause blood sugar to drop further when taken with repaglinide.
What To Do
Your doctor may need to lower your repaglinide dose and you should check your blood sugar levels more often.
FDA Label Information
Examples: beta-blockers, clonidine, guanethidine, and reserpine Clopidogrel : Avoid concomitant use; if used concomitantly initiate at 0.5 mg before each meal and limit total daily dose to 4 mg (7) Cyclosporine : Limit daily dose of repaglinide to 6 mg and increase frequency of glucose monitoring when co-administered (7) CYP2C8 and CYP3A4 Inhibitors and Drugs That May Increase the Risk of Hypoglycemia : Co-administration may require repaglinide dose reductions and increased frequency of glucose monitoring (7) CYP2C8 and CYP3A4 Inducers and Drugs That May Decrease the Blood Glucose Lowering...
Repaglinide Also Interacts With
- Gemfibrozil major
- Clarithromycin major
- Cyclosporine moderate
- Rifampin moderate
- Albuterol minor
Clonidine Also Interacts With
- Carvedilol moderate
- Metoprolol moderate
- Sotalol moderate
- Amitriptyline minor
- Diltiazem minor
Frequently Asked Questions
Can I take Repaglinide and Clonidine together?
This is a moderate interaction. Your doctor may need to lower your repaglinide dose and you should check your blood sugar levels more often.
How serious is the interaction between Repaglinide and Clonidine?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Repaglinide and Clonidine interact?
Clonidine can hide the warning signs of low blood sugar and may also cause blood sugar to drop further when taken with repaglinide.
Understanding the Repaglinide and Clonidine Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Repaglinide belongs to the Meglitinide class and Clonidine belongs to the Central Alpha-2 Agonist class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Clonidine can hide the warning signs of low blood sugar and may also cause blood sugar to drop further when taken with repaglinide. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Repaglinide has 22 total documented interactions on file in this dataset, and Clonidine has 29. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor may need to lower your repaglinide dose and you should check your blood sugar levels more often. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Repaglinide or Clonidine based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.