Repaglinide and Cyclosporine Interaction
Drug interaction information between Repaglinide and Cyclosporine.
Repaglinide and Cyclosporine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Repaglinide and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cyclosporine causes the amount of repaglinide in your blood to increase, which can make your blood sugar drop too low.
FDA Label Information
Cyclosporine Clinical Impact: Cyclosporine increased low dose repaglinide exposures by 2.5 fold [see Clinical Pharmacology (12.3) ] Intervention: Daily maximum repaglinide dose should be limited to 6 mg, and increased frequency of glucose monitoring may be required when repaglinide is co-administered with cyclosporine. Examples: beta-blockers, clonidine, guanethidine, and reserpine Clopidogrel : Avoid concomitant use; if used concomitantly initiate at 0.5 mg before each meal and limit total daily dose to 4 mg (7) Cyclosporine : Limit daily dose of repaglinide to 6 mg and increase frequency...
Repaglinide Also Interacts With
- Gemfibrozil major
- Clarithromycin major
- Clonidine moderate
- Rifampin moderate
- Albuterol minor
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Repaglinide + Cyclosporine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Repaglinide's 22. In the moderate band specifically: Repaglinide has 3 (also Clonidine, Rifampin); Cyclosporine has 24 (also Aliskiren, Allopurinol, Amiloride, Amlodipine/Valsartan).
What mechanism field is on file for Repaglinide and Cyclosporine?
Cyclosporine causes the amount of repaglinide in your blood to increase, which can make your blood sugar drop too low.
Cyclosporine carries more major-labeled pairs than Repaglinide
SPL source-record counts only. This page's band is moderate · classes on file: Repaglinide (Meglitinide); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Cyclosporine has 5 major-labeled pairs vs Repaglinide's 2. This page itself is in the moderate band, not the major band.
2 major · 3 moderate · 17 minor · 22 total
5 major · 24 moderate · 60 minor · 89 total
- Other moderate peers for Cyclosporine
- Aliskiren
- Allopurinol
- Amiloride
- Amlodipine/Valsartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.