What the FDA labels say about taking them together
Montelukast and repaglinide
Repaglinide's FDA label of May 2, 2025 names montelukast in its drug interactions section; the montelukast label PlainMeds reads does not name repaglinide. The repaglinide label: “… Drugs that are known to inhibit CYP2C8 include trimethoprim, gemfibrozil, montelukast, deferasirox, and clopidiogrel.”
Check it at the source: the montelukast FDA label on DailyMed (effective April 30, 2025, Organon LLC); the repaglinide FDA label on DailyMed (effective May 2, 2025, Chartwell RX, LLC).
What does the montelukast label say about repaglinide?
Montelukast's label (effective April 30, 2025) does not name repaglinide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (SINGULAIR), Organon LLC, effective April 30, 2025 (SPL set 482dcc92-b47f-4ea6-854a-f5ac2aea7842), via openFDA; the full label on DailyMed
What does the repaglinide label say about montelukast?
Repaglinide label, drug interactionsCYP2C8 and CYP3A4 Inhibitors Intervention: Repaglinide tablets dose reductions and increased frequency of glucose monitoring may be required when co-administered. Examples: Drugs that are known to inhibit CYP3A4 include antifungal agents (ketoconazole, itraconazole) and antibacterial agents (clarithromycin, erythromycin). Drugs that are known to inhibit CYP2C8 include trimethoprim, gemfibrozil, montelukast, deferasirox, and clopidiogrel.
Source: FDA drug label (Repaglinide), Chartwell RX, LLC, effective May 2, 2025 (SPL set cb995e92-295e-4638-a064-978211f5afe1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Montelukast | Repaglinide | |
|---|---|---|
| Labeled for | Asthma, Allergies | Type 2 diabetes |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0419 per tablet 10 mg tablet | $0.0987 per tablet 1 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once