Repaglinide and Montelukast Interaction
Drug interaction information between Repaglinide and Montelukast.
Repaglinide and Montelukast have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Repaglinide and Montelukast. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Montelukast blocks the liver enzyme that breaks down repaglinide, which can cause the drug to build up in your system.
FDA Label Information
Drugs that are known to inhibit CYP2C8 include trimethoprim, gemfibrozil, montelukast, deferasirox, and clopidiogrel.
Repaglinide Also Interacts With
- Gemfibrozil major
- Clarithromycin major
- Clonidine moderate
- Cyclosporine moderate
- Rifampin moderate
Montelukast Also Interacts With
- Prednisone minor
- Warfarin minor
- Prednisolone minor
- Itraconazole minor
- Digoxin minor
Frequently Asked Questions
What SPL severity band is on file for Repaglinide + Montelukast?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Repaglinide has 22 labeled pairs on file vs Montelukast's 8. In the minor band specifically: Repaglinide has 17 (also Albuterol, Fluoxetine, Ketoconazole, Olanzapine); Montelukast has 8 (also Prednisone, Warfarin, Prednisolone, Itraconazole).
What mechanism field is on file for Repaglinide and Montelukast?
Montelukast blocks the liver enzyme that breaks down repaglinide, which can cause the drug to build up in your system.
Repaglinide carries more major-labeled pairs than Montelukast
SPL source-record counts only. This page's band is minor · classes on file: Repaglinide (Meglitinide); Montelukast (Leukotriene Receptor Antagonist).
Repaglinide has 2 major-labeled pairs vs Montelukast's 0. This page itself is in the minor band, not the major band.
2 major · 3 moderate · 17 minor · 22 total
- Other minor peers for Repaglinide
- Albuterol
- Fluoxetine
- Ketoconazole
- Olanzapine
0 major · 0 moderate · 8 minor · 8 total
- Other minor peers for Montelukast
- Prednisone
- Warfarin
- Prednisolone
- Itraconazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.