Repaglinide and Rifampin Interaction
Drug interaction information between Repaglinide and Rifampin.
Repaglinide and Rifampin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Repaglinide and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin changes how your body processes repaglinide, which can increase the risk of your blood sugar dropping too low.
FDA Label Information
Examples: Drugs that induce the CYP3A4 and/or 2C8 enzyme systems include rifampin, barbiturates, and carbamezapine Drugs That May Increase the Risk of Hypoglycemia Intervention: Repaglinide dose reductions and increased frequency of glucose monitoring may be required when co-administered.
Repaglinide Also Interacts With
- Gemfibrozil major
- Clarithromycin major
- Clonidine moderate
- Cyclosporine moderate
- Albuterol minor
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Repaglinide + Rifampin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Repaglinide's 22. In the moderate band specifically: Repaglinide has 3 (also Clonidine, Cyclosporine); Rifampin has 26 (also Doxycycline, Probenecid, Theophylline, Apixaban).
What mechanism field is on file for Repaglinide and Rifampin?
Rifampin changes how your body processes repaglinide, which can increase the risk of your blood sugar dropping too low.
Rifampin carries more major-labeled pairs than Repaglinide
SPL source-record counts only. This page's band is moderate · classes on file: Repaglinide (Meglitinide); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Repaglinide's 2. This page itself is in the moderate band, not the major band.
2 major · 3 moderate · 17 minor · 22 total
- Other moderate peers for Repaglinide
- Clonidine
- Cyclosporine
8 major · 26 moderate · 103 minor · 137 total
- Other moderate peers for Rifampin
- Doxycycline
- Probenecid
- Theophylline
- Apixaban
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.