Repaglinide and Clarithromycin Interaction
Drug interaction information between Repaglinide and Clarithromycin.
Repaglinide and Clarithromycin have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Repaglinide and Clarithromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clarithromycin interferes with the enzyme that processes repaglinide, which can cause the medicine to stay in your system longer and drop your blood sugar too low.
FDA Label Information
Gastroprokinetic Agents: Cisapride Contraindicated Cisapride: [See Contraindications ( 4.2 )] Lipid-lowering agents: Lomitapide Lovastatin Simvastatin Contraindicated Lomitapide, Lovastatin, Simvastatin: Clarithromycin may increase the exposure of these drugs by inhibition of CYP3A metabolism, thereby increasing the risk of toxicities from these drugs [see Contraindications ( 4.5 ) and Warnings and Precautions ( 5.4 )] Atorvastatin, Pravastatin, Fluvastatin: [See Warnings and Precautions ( 5.4 )] Atorvastatin Pravastatin Use With Caution Fluvastatin No Dose Adjustment Hypoglycemic Agents:...
Repaglinide Also Interacts With
- Gemfibrozil major
- Clonidine moderate
- Cyclosporine moderate
- Rifampin moderate
- Albuterol minor
Clarithromycin Also Interacts With
- Quetiapine major
- Pioglitazone major
- Fluconazole major
- Cyclosporine major
- Lurasidone major
Frequently Asked Questions
What SPL severity band is on file for Repaglinide + Clarithromycin?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clarithromycin has 81 labeled pairs on file vs Repaglinide's 22. In the major band specifically: Repaglinide has 2 (also Gemfibrozil); Clarithromycin has 16 (also Quetiapine, Pioglitazone, Fluconazole, Cyclosporine).
What mechanism field is on file for Repaglinide and Clarithromycin?
Clarithromycin interferes with the enzyme that processes repaglinide, which can cause the medicine to stay in your system longer and drop your blood sugar too low.
Clarithromycin carries more major-labeled pairs than Repaglinide
SPL source-record counts only. This page's band is major · classes on file: Repaglinide (Meglitinide); Clarithromycin (Macrolide Antibiotic).
Clarithromycin has 16 major-labeled pairs vs Repaglinide's 2.
2 major · 3 moderate · 17 minor · 22 total
- Other major peers for Repaglinide
- Gemfibrozil
16 major · 35 moderate · 30 minor · 81 total
- Other major peers for Clarithromycin
- Quetiapine
- Pioglitazone
- Fluconazole
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.