Pramlintide and Insulin Aspart Interaction
Drug interaction information between Pramlintide and Insulin Aspart.
Pramlintide and Insulin Aspart have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Pramlintide and Insulin Aspart. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medications are used to lower blood sugar, so taking them together increases the chance of your blood sugar falling to a dangerous level.
FDA Label Information
Drugs That May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analog (e.g., octreotide), and sulfonamide antibiotics. • Drugs that may increase the risk of hypoglycemia: antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analog (e.g., octreotide), and...
Pramlintide Also Interacts With
- Insulin Degludec moderate
- Insulin Detemir moderate
- Insulin Glargine moderate
- Insulin Glulisine moderate
- Insulin Human/Insulin Isophane moderate
Insulin Aspart Also Interacts With
- Fluoxetine moderate
- Octreotide moderate
- Albuterol minor
- Clonidine minor
- Olanzapine minor
Frequently Asked Questions
What SPL severity band is on file for Pramlintide + Insulin Aspart?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Pramlintide has 13 labeled pairs on file vs Insulin Aspart's 11. In the moderate band specifically: Pramlintide has 9 (also Insulin Degludec, Insulin Detemir, Insulin Glargine, Insulin Glulisine); Insulin Aspart has 3 (also Fluoxetine, Octreotide).
What mechanism field is on file for Pramlintide and Insulin Aspart?
Both of these medications are used to lower blood sugar, so taking them together increases the chance of your blood sugar falling to a dangerous level.
Pramlintide's labeled portfolio outnumbers Insulin Aspart
SPL source-record counts only. This page's band is moderate · classes on file: Pramlintide (Amylin Analog); Insulin Aspart (Rapid-Acting Insulin).
0 major · 9 moderate · 4 minor · 13 total
- Other moderate peers for Pramlintide
- Insulin Degludec
- Insulin Detemir
- Insulin Glargine
- Insulin Glulisine
0 major · 3 moderate · 8 minor · 11 total
- Other moderate peers for Insulin Aspart
- Fluoxetine
- Octreotide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.