Acetaminophen/Oxycodone and Cyclobenzaprine Interaction
Drug interaction information between Acetaminophen/Oxycodone and Cyclobenzaprine.
Acetaminophen/Oxycodone and Cyclobenzaprine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Acetaminophen/Oxycodone and Cyclobenzaprine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs increase serotonin levels in the brain, which can cause a serious reaction called serotonin syndrome.
FDA Label Information
Serotonergic Drugs The concomitant use of opioids with other drugs that affect the serotonergic neurotransmitter system, such as selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), tryptans, 5-HT3 receptor antagonists, drugs that affect the serotonin neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), certain muscle relaxants (i.e., cyclobenzaprine, metaxalone), and monoamine oxidase (MAO) inhibitors (those intended to treat psychiatric disorders and also others, such as linezolid and...
Acetaminophen/Oxycodone Also Interacts With
- Gabapentin moderate
- Pregabalin moderate
- Trazodone minor
- Tramadol minor
- Oxycodone minor
Cyclobenzaprine Also Interacts With
- Clozapine moderate
- Tapentadol moderate
- Tranylcypromine moderate
- Buprenorphine minor
- Buprenorphine/Naloxone minor
Frequently Asked Questions
What SPL severity band is on file for Acetaminophen/Oxycodone + Cyclobenzaprine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Acetaminophen/Oxycodone has 23 labeled pairs on file vs Cyclobenzaprine's 17. In the minor band specifically: Acetaminophen/Oxycodone has 21 (also Trazodone, Tramadol, Oxycodone, Lamotrigine); Cyclobenzaprine has 14 (also Buprenorphine, Buprenorphine/Naloxone, Buprenorphine, Codeine).
What mechanism field is on file for Acetaminophen/Oxycodone and Cyclobenzaprine?
Both drugs increase serotonin levels in the brain, which can cause a serious reaction called serotonin syndrome.
Acetaminophen/Oxycodone's labeled portfolio outnumbers Cyclobenzaprine
SPL source-record counts only. This page's band is minor · classes on file: Acetaminophen/Oxycodone (Opioid Analgesic Combination); Cyclobenzaprine (Muscle Relaxant).
0 major · 2 moderate · 21 minor · 23 total
- Other minor peers for Acetaminophen/Oxycodone
- Trazodone
- Tramadol
- Oxycodone
- Lamotrigine
0 major · 3 moderate · 14 minor · 17 total
- Other minor peers for Cyclobenzaprine
- Buprenorphine
- Buprenorphine/Naloxone
- Buprenorphine
- Codeine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.