Acetaminophen/Oxycodone and Gabapentin Interaction
Drug interaction information between Acetaminophen/Oxycodone and Gabapentin.
Acetaminophen/Oxycodone and Gabapentin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Acetaminophen/Oxycodone and Gabapentin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these drugs slow down the central nervous system. Taking them together can cause extreme sleepiness, dangerously slow breathing, coma, or even death.
FDA Label Information
Benzodiazepines and Other Central Nervous System (CNS) Depressants Due to additive pharmacologic effect, the concomitant use of benzodiazepines and other CNS depressants such as benzodiazepines and other sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids (gabapentin or pregabalin), other opioids, including alcohol, can increase the risk of hypotension, respiratory depression, profound sedation, coma, and death.
Acetaminophen/Oxycodone Also Interacts With
- Pregabalin moderate
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
- Oxycodone minor
Gabapentin Also Interacts With
- Oxycodone minor
- Estradiol minor
- Naproxen minor
- Norethindrone minor
- Morphine minor
Frequently Asked Questions
What SPL severity band is on file for Acetaminophen/Oxycodone + Gabapentin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Acetaminophen/Oxycodone has 23 labeled pairs on file vs Gabapentin's 19. In the moderate band specifically: Acetaminophen/Oxycodone has 2 (also Pregabalin); Gabapentin has 1.
What mechanism field is on file for Acetaminophen/Oxycodone and Gabapentin?
Both of these drugs slow down the central nervous system. Taking them together can cause extreme sleepiness, dangerously slow breathing, coma, or even death.
Acetaminophen/Oxycodone's labeled portfolio outnumbers Gabapentin
SPL source-record counts only. This page's band is moderate · classes on file: Acetaminophen/Oxycodone (Opioid Analgesic Combination); Gabapentin (Anticonvulsant / Nerve Pain Agent).
0 major · 2 moderate · 21 minor · 23 total
- Other moderate peers for Acetaminophen/Oxycodone
- Pregabalin
0 major · 1 moderate · 18 minor · 19 total
Gabapentin has no other moderate-band peer in this dataset besides Acetaminophen/Oxycodone.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.