Acetaminophen/Oxycodone and Oxycodone Interaction
Drug interaction information between Acetaminophen/Oxycodone and Oxycodone.
Acetaminophen/Oxycodone and Oxycodone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Acetaminophen/Oxycodone and Oxycodone. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Taking both of these medications increases the total amount of oxycodone in your blood, which can lead to dangerous side effects.
What To Do
Do not take these two medicines together because they contain the same active ingredient.
FDA Label Information
ketoconazole), and protease inhibitors (e.g., ritonavir), can increase the plasma concentration of oxycodone, resulting in increased or prolonged opioid effects. After stopping a CYP3A4 inhibitor, as the effects of the inhibitor decline, the oxycodone plasma concentration will decrease [see CLINICAL PHARMACOLOGY ] , resulting in decreased opioid efficacy or a withdrawal syndrome in patients who had developed physical dependence to PERCOCET. Inducers of CYP3A4 The concomitant use of PERCOCET and CYP3A4 inducers, such as rifampin, carbamazepine, and phenytoin, can decrease the plasma...
Acetaminophen/Oxycodone Also Interacts With
- Gabapentin moderate
- Pregabalin moderate
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
Oxycodone Also Interacts With
- Carbamazepine moderate
- Rifampin moderate
- Buprenorphine moderate
- Butorphanol moderate
- Nalbuphine moderate
Frequently Asked Questions
Can I take Acetaminophen/Oxycodone and Oxycodone together?
This is a minor interaction. Do not take these two medicines together because they contain the same active ingredient.
How serious is the interaction between Acetaminophen/Oxycodone and Oxycodone?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Acetaminophen/Oxycodone and Oxycodone interact?
Taking both of these medications increases the total amount of oxycodone in your blood, which can lead to dangerous side effects.
Understanding the Acetaminophen/Oxycodone and Oxycodone Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Acetaminophen/Oxycodone belongs to the Opioid Analgesic Combination class and Oxycodone belongs to the Opioid Analgesic class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Taking both of these medications increases the total amount of oxycodone in your blood, which can lead to dangerous side effects. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Acetaminophen/Oxycodone has 23 total documented interactions on file in this dataset, and Oxycodone has 28. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Do not take these two medicines together because they contain the same active ingredient. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Acetaminophen/Oxycodone or Oxycodone based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.