Acetaminophen/Oxycodone and Oxycodone Interaction
Drug interaction information between Acetaminophen/Oxycodone and Oxycodone.
Acetaminophen/Oxycodone and Oxycodone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Acetaminophen/Oxycodone and Oxycodone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking both of these medications increases the total amount of oxycodone in your blood, which can lead to dangerous side effects.
FDA Label Information
ketoconazole), and protease inhibitors (e.g., ritonavir), can increase the plasma concentration of oxycodone, resulting in increased or prolonged opioid effects. After stopping a CYP3A4 inhibitor, as the effects of the inhibitor decline, the oxycodone plasma concentration will decrease [see CLINICAL PHARMACOLOGY ] , resulting in decreased opioid efficacy or a withdrawal syndrome in patients who had developed physical dependence to PERCOCET. Inducers of CYP3A4 The concomitant use of PERCOCET and CYP3A4 inducers, such as rifampin, carbamazepine, and phenytoin, can decrease the plasma...
Acetaminophen/Oxycodone Also Interacts With
- Gabapentin moderate
- Pregabalin moderate
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
Oxycodone Also Interacts With
- Carbamazepine moderate
- Rifampin moderate
- Buprenorphine moderate
- Butorphanol moderate
- Nalbuphine moderate
Frequently Asked Questions
What SPL severity band is on file for Acetaminophen/Oxycodone + Oxycodone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Oxycodone has 28 labeled pairs on file vs Acetaminophen/Oxycodone's 23. In the minor band specifically: Acetaminophen/Oxycodone has 21 (also Trazodone, Tramadol, Cyclobenzaprine, Lamotrigine); Oxycodone has 22 (also Trazodone, Tramadol, Cyclobenzaprine, Pregabalin).
What mechanism field is on file for Acetaminophen/Oxycodone and Oxycodone?
Taking both of these medications increases the total amount of oxycodone in your blood, which can lead to dangerous side effects.
Oxycodone's labeled portfolio outnumbers Acetaminophen/Oxycodone
SPL source-record counts only. This page's band is minor · classes on file: Acetaminophen/Oxycodone (Opioid Analgesic Combination); Oxycodone (Opioid Analgesic).
0 major · 2 moderate · 21 minor · 23 total
- Other minor peers for Acetaminophen/Oxycodone
- Trazodone
- Tramadol
- Cyclobenzaprine
- Lamotrigine
0 major · 6 moderate · 22 minor · 28 total
- Other minor peers for Oxycodone
- Trazodone
- Tramadol
- Cyclobenzaprine
- Pregabalin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.