Nirmatrelvir/Ritonavir and Buspirone Interaction
Drug interaction information between Nirmatrelvir/Ritonavir and Buspirone.
Nirmatrelvir/Ritonavir and Buspirone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Nirmatrelvir/Ritonavir and Buspirone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Paxlovid slows down how your body processes buspirone, which can cause the drug to build up and make you feel more sleepy.
FDA Label Information
Sedative/hypnotics buspirone, clorazepate, diazepam, estazolam, flurazepam, zolpidem ↑ sedative/hypnotic A dose decrease may be needed for these drugs when co-administered with PAXLOVID and monitoring for adverse events.
Nirmatrelvir/Ritonavir Also Interacts With
- Simvastatin major
- Lovastatin major
- Sildenafil major
- Carbamazepine major
- Rifampin major
Buspirone Also Interacts With
- Tranylcypromine moderate
- Ziprasidone moderate
- Citalopram minor
- Darunavir minor
- Desvenlafaxine minor
Frequently Asked Questions
What SPL severity band is on file for Nirmatrelvir/Ritonavir + Buspirone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Nirmatrelvir/Ritonavir has 86 labeled pairs on file vs Buspirone's 17. In the minor band specifically: Nirmatrelvir/Ritonavir has 33 (also Atorvastatin, Bupropion, Trazodone, Prednisone); Buspirone has 15 (also Citalopram, Darunavir, Desvenlafaxine, Diltiazem).
What mechanism field is on file for Nirmatrelvir/Ritonavir and Buspirone?
Paxlovid slows down how your body processes buspirone, which can cause the drug to build up and make you feel more sleepy.
Nirmatrelvir/Ritonavir carries more major-labeled pairs than Buspirone
SPL source-record counts only. This page's band is minor · classes on file: Nirmatrelvir/Ritonavir (Antiviral (Protease Inhibitor Combination)); Buspirone (Azapirone Anxiolytic).
Nirmatrelvir/Ritonavir has 23 major-labeled pairs vs Buspirone's 0. This page itself is in the minor band, not the major band.
23 major · 30 moderate · 33 minor · 86 total
- Other minor peers for Nirmatrelvir/Ritonavir
- Atorvastatin
- Bupropion
- Trazodone
- Prednisone
0 major · 2 moderate · 15 minor · 17 total
- Other minor peers for Buspirone
- Citalopram
- Darunavir
- Desvenlafaxine
- Diltiazem
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.