Niacin and Ezetimibe/Simvastatin Interaction
Drug interaction information between Niacin and Ezetimibe/Simvastatin.
Niacin and Ezetimibe/Simvastatin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Niacin and Ezetimibe/Simvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking high doses of niacin with this drug increases the risk of muscle damage and may not provide extra heart benefits.
FDA Label Information
Niacin Clinical Impact: Cases of myopathy and rhabdomyolysis have been observed with concomitant use of lipid modifying dosages of niacin-containing products (≥1 gram/day niacin) with VYTORIN. In a clinical trial (median follow-up 3.9 years) of patients at high risk of CVD and with well-controlled LDL-C levels on simvastatin 40 mg/day with or without ezetimibe 10 mg/day, there was no incremental benefit on cardiovascular outcomes with the addition of lipid-modifying doses of niacin Intervention: Concomitant use of VYTORIN with lipid-modifying dosages of niacin is not recommended in Chinese...
Niacin Also Interacts With
- Atorvastatin moderate
- Ezetimibe moderate
- Fluvastatin moderate
- Lovastatin moderate
- Pitavastatin moderate
Ezetimibe/Simvastatin Also Interacts With
- Amlodipine major
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
Frequently Asked Questions
What SPL severity band is on file for Niacin + Ezetimibe/Simvastatin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ezetimibe/Simvastatin has 23 labeled pairs on file vs Niacin's 21. In the moderate band specifically: Niacin has 10 (also Atorvastatin, Ezetimibe, Fluvastatin, Lovastatin); Ezetimibe/Simvastatin has 4 (also Simvastatin, Daptomycin, Colchicine).
What mechanism field is on file for Niacin and Ezetimibe/Simvastatin?
Taking high doses of niacin with this drug increases the risk of muscle damage and may not provide extra heart benefits.
Ezetimibe/Simvastatin carries more major-labeled pairs than Niacin
SPL source-record counts only. This page's band is moderate · classes on file: Niacin (Vitamin B3 (Lipid-Modifying)); Ezetimibe/Simvastatin (Cholesterol Absorption Inhibitor / Statin Combination).
Ezetimibe/Simvastatin has 8 major-labeled pairs vs Niacin's 0. This page itself is in the moderate band, not the major band.
0 major · 10 moderate · 11 minor · 21 total
- Other moderate peers for Niacin
- Atorvastatin
- Ezetimibe
- Fluvastatin
- Lovastatin
8 major · 4 moderate · 11 minor · 23 total
- Other moderate peers for Ezetimibe/Simvastatin
- Simvastatin
- Daptomycin
- Colchicine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.