Ezetimibe/Simvastatin and Cyclosporine Interaction
Drug interaction information between Ezetimibe/Simvastatin and Cyclosporine.
Ezetimibe/Simvastatin and Cyclosporine have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Ezetimibe/Simvastatin and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cyclosporine causes a large increase in simvastatin levels in your blood, which can lead to a dangerous condition where muscle tissue breaks down.
FDA Label Information
Cyclosporine, Danazol, or Gemfibrozil Clinical Impact: The risk of myopathy and rhabdomyolysis is increased with concomitant use of cyclosporine, danazol, or gemfibrozil with VYTORIN. Intervention: Concomitant use of cyclosporine, danazol, or gemfibrozil with VYTORIN is contraindicated [see Contraindications (4) ] .
Ezetimibe/Simvastatin Also Interacts With
- Amlodipine major
- Diltiazem major
- Verapamil major
- Amiodarone major
- Dronedarone major
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Pitavastatin major
- Simvastatin major
- Aliskiren moderate
Frequently Asked Questions
What SPL severity band is on file for Ezetimibe/Simvastatin + Cyclosporine?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Ezetimibe/Simvastatin's 23. In the major band specifically: Ezetimibe/Simvastatin has 8 (also Amlodipine, Diltiazem, Verapamil, Amiodarone); Cyclosporine has 5 (also Clarithromycin, Ezetimibe, Pitavastatin, Simvastatin).
What mechanism field is on file for Ezetimibe/Simvastatin and Cyclosporine?
Cyclosporine causes a large increase in simvastatin levels in your blood, which can lead to a dangerous condition where muscle tissue breaks down.
Ezetimibe/Simvastatin carries more major-labeled pairs than Cyclosporine
SPL source-record counts only. This page's band is major · classes on file: Ezetimibe/Simvastatin (Cholesterol Absorption Inhibitor / Statin Combination); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Ezetimibe/Simvastatin has 8 major-labeled pairs vs Cyclosporine's 5.
8 major · 4 moderate · 11 minor · 23 total
- Other major peers for Ezetimibe/Simvastatin
- Amlodipine
- Diltiazem
- Verapamil
- Amiodarone
5 major · 24 moderate · 60 minor · 89 total
- Other major peers for Cyclosporine
- Clarithromycin
- Ezetimibe
- Pitavastatin
- Simvastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.