Niacin and Pitavastatin Interaction
Drug interaction information between Niacin and Pitavastatin.
Niacin and Pitavastatin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Niacin and Pitavastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using high doses of niacin along with this statin can increase your chances of having severe muscle pain or injury.
FDA Label Information
Niacin Clinical Impact: The risk of myopathy and rhabdomyolysis may be increased with concomitant use of lipid-modifying doses (≥1 g/day) of niacin with pitavastatin tablets. Intervention: Consider if the benefit of using lipid-modifying doses (≥1 g/day) of niacin concomitantly with pitavastatin tablets outweighs the increased risk of myopathy and rhabdomyolysis.
Niacin Also Interacts With
- Atorvastatin moderate
- Ezetimibe moderate
- Ezetimibe/Simvastatin moderate
- Fluvastatin moderate
- Lovastatin moderate
Pitavastatin Also Interacts With
- Cyclosporine major
- Erythromycin major
- Rifampin major
- Colchicine moderate
- Gemfibrozil moderate
Frequently Asked Questions
What SPL severity band is on file for Niacin + Pitavastatin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Niacin has 21 labeled pairs on file vs Pitavastatin's 9. In the moderate band specifically: Niacin has 10 (also Atorvastatin, Ezetimibe, Ezetimibe/Simvastatin, Fluvastatin); Pitavastatin has 4 (also Colchicine, Gemfibrozil, Sofosbuvir/Velpatasvir).
What mechanism field is on file for Niacin and Pitavastatin?
Using high doses of niacin along with this statin can increase your chances of having severe muscle pain or injury.
Pitavastatin carries more major-labeled pairs than Niacin
SPL source-record counts only. This page's band is moderate · classes on file: Niacin (Vitamin B3 (Lipid-Modifying)); Pitavastatin (HMG-CoA Reductase Inhibitor (Statin)).
Pitavastatin has 3 major-labeled pairs vs Niacin's 0. This page itself is in the moderate band, not the major band.
0 major · 10 moderate · 11 minor · 21 total
- Other moderate peers for Niacin
- Atorvastatin
- Ezetimibe
- Ezetimibe/Simvastatin
- Fluvastatin
3 major · 4 moderate · 2 minor · 9 total
- Other moderate peers for Pitavastatin
- Colchicine
- Gemfibrozil
- Sofosbuvir/Velpatasvir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.