Ezetimibe/Simvastatin and Verapamil Interaction
Drug interaction information between Ezetimibe/Simvastatin and Verapamil.
Ezetimibe/Simvastatin and Verapamil have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Ezetimibe/Simvastatin and Verapamil. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Verapamil prevents your body from processing simvastatin correctly, causing the drug to build up to high levels. This can lead to severe muscle pain or weakness.
FDA Label Information
Intervention: For patients taking verapamil, diltiazem, or dronedarone, do not exceed VYTORIN 10/10 mg daily.
Ezetimibe/Simvastatin Also Interacts With
- Amlodipine major
- Diltiazem major
- Cyclosporine major
- Amiodarone major
- Dronedarone major
Verapamil Also Interacts With
- Eplerenone major
- Ezetimibe major
- Simvastatin major
- Clarithromycin moderate
- Lovastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Ezetimibe/Simvastatin + Verapamil?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Verapamil has 57 labeled pairs on file vs Ezetimibe/Simvastatin's 23. In the major band specifically: Ezetimibe/Simvastatin has 8 (also Amlodipine, Diltiazem, Cyclosporine, Amiodarone); Verapamil has 4 (also Eplerenone, Ezetimibe, Simvastatin).
What mechanism field is on file for Ezetimibe/Simvastatin and Verapamil?
Verapamil prevents your body from processing simvastatin correctly, causing the drug to build up to high levels. This can lead to severe muscle pain or weakness.
Ezetimibe/Simvastatin carries more major-labeled pairs than Verapamil
SPL source-record counts only. This page's band is major · classes on file: Ezetimibe/Simvastatin (Cholesterol Absorption Inhibitor / Statin Combination); Verapamil (Calcium Channel Blocker).
Ezetimibe/Simvastatin has 8 major-labeled pairs vs Verapamil's 4.
8 major · 4 moderate · 11 minor · 23 total
- Other major peers for Ezetimibe/Simvastatin
- Amlodipine
- Diltiazem
- Cyclosporine
- Amiodarone
4 major · 6 moderate · 47 minor · 57 total
- Other major peers for Verapamil
- Eplerenone
- Ezetimibe
- Simvastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.