What the FDA labels say about taking them together
Amlodipine and ezetimibe/simvastatin
Ezetimibe/simvastatin's FDA label of January 21, 2026 names amlodipine in its drug interactions section; the amlodipine labels PlainMeds reads (4) do not name ezetimibe/simvastatin. The ezetimibe/simvastatin label: “For patients taking amiodarone, amlodipine, or ranolazine, do not exceed VYTORIN 10/20 mg daily.”
Check it at the source: the amlodipine FDA label on DailyMed (effective February 15, 2023, Viatris Specialty LLC); the ezetimibe/simvastatin FDA label on DailyMed (effective January 21, 2026, Organon LLC).
What does the amlodipine label say about ezetimibe/simvastatin?
Amlodipine's label (effective February 15, 2023) and its 3 other brand-application labels do not name ezetimibe/simvastatin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Norvasc), Viatris Specialty LLC, effective February 15, 2023 (SPL set 7367289c-b0b0-466a-83e2-558e2985c29f), via openFDA; the full label on DailyMed
What does the ezetimibe/simvastatin label say about amlodipine?
Ezetimibe/simvastatin label, drug interactionsFor patients taking amiodarone, amlodipine, or ranolazine, do not exceed VYTORIN 10/20 mg daily [see Dosage and Administration (2.3) ].
Ezetimibe/simvastatin label, warnings and precautionsVYTORIN dosage modifications are recommended for patients taking lomitapide, verapamil, diltiazem, dronedarone, amiodarone, amlodipine or ranolazine [see Dosage and Administration (2.5) ].
Source: FDA drug label (VYTORIN), Organon LLC, effective January 21, 2026 (SPL set 89b860d2-de83-468e-b7e8-76aeec2edca2), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
These are the ingredient's own label sentences, repeated in a combination product's or a biosimilar's label. The ingredient pair sets them out with both labels side by side.
Both medicines on the record
| Amlodipine | Ezetimibe/simvastatin | |
|---|---|---|
| Labeled for | High blood pressure, Angina, Heart attack and coronary artery disease | High cholesterol, Heart attack and coronary artery disease |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0102 per tablet 5 mg tablet | $0.285 per unit 10-80 mg |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once