Ezetimibe/Simvastatin and Amlodipine Interaction
Drug interaction information between Ezetimibe/Simvastatin and Amlodipine.
Ezetimibe/Simvastatin and Amlodipine have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Ezetimibe/Simvastatin and Amlodipine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Amlodipine can cause the cholesterol medication to stay in your system longer, which increases the chance of muscle pain or weakness.
FDA Label Information
For patients taking amiodarone, amlodipine, or ranolazine, do not exceed VYTORIN 10/20 mg daily [see Dosage and Administration (2.3) ] .
Ezetimibe/Simvastatin Also Interacts With
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
- Dronedarone major
Amlodipine Also Interacts With
- Simvastatin major
- Amlodipine/Benazepril major
- Ezetimibe major
- Nirmatrelvir/Ritonavir moderate
- Sildenafil minor
Frequently Asked Questions
What SPL severity band is on file for Ezetimibe/Simvastatin + Amlodipine?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ezetimibe/Simvastatin has 23 labeled pairs on file vs Amlodipine's 15. In the major band specifically: Ezetimibe/Simvastatin has 8 (also Diltiazem, Verapamil, Cyclosporine, Amiodarone); Amlodipine has 4 (also Simvastatin, Amlodipine/Benazepril, Ezetimibe).
What mechanism field is on file for Ezetimibe/Simvastatin and Amlodipine?
Amlodipine can cause the cholesterol medication to stay in your system longer, which increases the chance of muscle pain or weakness.
Ezetimibe/Simvastatin carries more major-labeled pairs than Amlodipine
SPL source-record counts only. This page's band is major · classes on file: Ezetimibe/Simvastatin (Cholesterol Absorption Inhibitor / Statin Combination); Amlodipine (Calcium Channel Blocker).
Ezetimibe/Simvastatin has 8 major-labeled pairs vs Amlodipine's 4.
8 major · 4 moderate · 11 minor · 23 total
- Other major peers for Ezetimibe/Simvastatin
- Diltiazem
- Verapamil
- Cyclosporine
- Amiodarone
4 major · 1 moderate · 10 minor · 15 total
- Other major peers for Amlodipine
- Simvastatin
- Amlodipine/Benazepril
- Ezetimibe
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.