Ezetimibe/Simvastatin and Simvastatin Interaction
Drug interaction information between Ezetimibe/Simvastatin and Simvastatin.
Ezetimibe/Simvastatin and Simvastatin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Ezetimibe/Simvastatin and Simvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Certain drugs block the body's ability to break down simvastatin, causing the medicine to build up to high levels in the blood. This buildup significantly increases the risk of dangerous muscle breakdown.
Ezetimibe/Simvastatin Also Interacts With
- Amlodipine major
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
Simvastatin Also Interacts With
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
- Dronedarone major
Frequently Asked Questions
What SPL severity band is on file for Ezetimibe/Simvastatin + Simvastatin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Simvastatin has 41 labeled pairs on file vs Ezetimibe/Simvastatin's 23. In the moderate band specifically: Ezetimibe/Simvastatin has 4 (also Daptomycin, Colchicine, Niacin); Simvastatin has 9 (also Ezetimibe, Daptomycin, Colchicine, Niacin).
What mechanism field is on file for Ezetimibe/Simvastatin and Simvastatin?
Certain drugs block the body's ability to break down simvastatin, causing the medicine to build up to high levels in the blood. This buildup significantly increases the risk of dangerous muscle breakdown.
Simvastatin carries more major-labeled pairs than Ezetimibe/Simvastatin
SPL source-record counts only. This page's band is moderate · classes on file: Ezetimibe/Simvastatin (Cholesterol Absorption Inhibitor / Statin Combination); Simvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Simvastatin has 11 major-labeled pairs vs Ezetimibe/Simvastatin's 8. This page itself is in the moderate band, not the major band.
8 major · 4 moderate · 11 minor · 23 total
- Other moderate peers for Ezetimibe/Simvastatin
- Daptomycin
- Colchicine
- Niacin
11 major · 9 moderate · 21 minor · 41 total
- Other moderate peers for Simvastatin
- Ezetimibe
- Daptomycin
- Colchicine
- Niacin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.