Niacin and Atorvastatin Interaction
Drug interaction information between Niacin and Atorvastatin.
Niacin and Atorvastatin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Niacin and Atorvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking high doses of niacin along with atorvastatin can increase your risk of developing severe muscle pain or damage.
FDA Label Information
Niacin Clinical Impact: Cases of myopathy and rhabdomyolysis have been observed with concomitant use of lipid modifying dosages of niacin ( > 1 gram/day niacin) with atorvastatin. Intervention: Consider if the benefit of using lipid modifying dosages of niacin concomitantly with atorvastatin outweighs the increased risk of myopathy and rhabdomyolysis.
Niacin Also Interacts With
- Ezetimibe moderate
- Ezetimibe/Simvastatin moderate
- Fluvastatin moderate
- Lovastatin moderate
- Pitavastatin moderate
Atorvastatin Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Cyclosporine moderate
- Colchicine moderate
Frequently Asked Questions
What SPL severity band is on file for Niacin + Atorvastatin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Atorvastatin has 36 labeled pairs on file vs Niacin's 21. In the moderate band specifically: Niacin has 10 (also Ezetimibe, Ezetimibe/Simvastatin, Fluvastatin, Lovastatin); Atorvastatin has 8 (also Cyclosporine, Colchicine, Gemfibrozil, Fluconazole).
What mechanism field is on file for Niacin and Atorvastatin?
Taking high doses of niacin along with atorvastatin can increase your risk of developing severe muscle pain or damage.
Atorvastatin carries more major-labeled pairs than Niacin
SPL source-record counts only. This page's band is moderate · classes on file: Niacin (Vitamin B3 (Lipid-Modifying)); Atorvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Atorvastatin has 3 major-labeled pairs vs Niacin's 0. This page itself is in the moderate band, not the major band.
0 major · 10 moderate · 11 minor · 21 total
- Other moderate peers for Niacin
- Ezetimibe
- Ezetimibe/Simvastatin
- Fluvastatin
- Lovastatin
3 major · 8 moderate · 25 minor · 36 total
- Other moderate peers for Atorvastatin
- Cyclosporine
- Colchicine
- Gemfibrozil
- Fluconazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.