Ezetimibe/Simvastatin and Amiodarone Interaction
Drug interaction information between Ezetimibe/Simvastatin and Amiodarone.
Ezetimibe/Simvastatin and Amiodarone have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Ezetimibe/Simvastatin and Amiodarone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Amiodarone slows the removal of simvastatin from your system, which increases the risk of muscle injury.
FDA Label Information
Amiodarone, Dronedarone, Ranolazine, or Calcium Channel Blockers Clinical Impact: The risk of myopathy and rhabdomyolysis is increased by concomitant use of amiodarone, dronedarone, ranolazine, or calcium channel blockers with VYTORIN. For patients taking amiodarone, amlodipine, or ranolazine, do not exceed VYTORIN 10/20 mg daily [see Dosage and Administration (2.3) ] .
Ezetimibe/Simvastatin Also Interacts With
- Amlodipine major
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Dronedarone major
Amiodarone Also Interacts With
- Ezetimibe major
- Nirmatrelvir/Ritonavir major
- Simvastatin major
- Lithium moderate
- Clarithromycin moderate
Frequently Asked Questions
What SPL severity band is on file for Ezetimibe/Simvastatin + Amiodarone?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amiodarone has 42 labeled pairs on file vs Ezetimibe/Simvastatin's 23. In the major band specifically: Ezetimibe/Simvastatin has 8 (also Amlodipine, Diltiazem, Verapamil, Cyclosporine); Amiodarone has 4 (also Ezetimibe, Nirmatrelvir/Ritonavir, Simvastatin).
What mechanism field is on file for Ezetimibe/Simvastatin and Amiodarone?
Amiodarone slows the removal of simvastatin from your system, which increases the risk of muscle injury.
Ezetimibe/Simvastatin carries more major-labeled pairs than Amiodarone
SPL source-record counts only. This page's band is major · classes on file: Ezetimibe/Simvastatin (Cholesterol Absorption Inhibitor / Statin Combination); Amiodarone (Class III Antiarrhythmic).
Ezetimibe/Simvastatin has 8 major-labeled pairs vs Amiodarone's 4.
8 major · 4 moderate · 11 minor · 23 total
- Other major peers for Ezetimibe/Simvastatin
- Amlodipine
- Diltiazem
- Verapamil
- Cyclosporine
4 major · 9 moderate · 29 minor · 42 total
- Other major peers for Amiodarone
- Ezetimibe
- Nirmatrelvir/Ritonavir
- Simvastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.