Ezetimibe/Simvastatin and Diltiazem Interaction
Drug interaction information between Ezetimibe/Simvastatin and Diltiazem.
Ezetimibe/Simvastatin and Diltiazem have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Ezetimibe/Simvastatin and Diltiazem. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Diltiazem slows down the breakdown of simvastatin in your body, which can lead to higher levels of the drug in your blood. This increases the risk of serious muscle damage.
FDA Label Information
Intervention: For patients taking verapamil, diltiazem, or dronedarone, do not exceed VYTORIN 10/10 mg daily.
Ezetimibe/Simvastatin Also Interacts With
- Amlodipine major
- Verapamil major
- Cyclosporine major
- Amiodarone major
- Dronedarone major
Diltiazem Also Interacts With
- Ezetimibe major
- Simvastatin major
- Theophylline major
- Rifampin moderate
- Digoxin moderate
Frequently Asked Questions
What SPL severity band is on file for Ezetimibe/Simvastatin + Diltiazem?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Diltiazem has 46 labeled pairs on file vs Ezetimibe/Simvastatin's 23. In the major band specifically: Ezetimibe/Simvastatin has 8 (also Amlodipine, Verapamil, Cyclosporine, Amiodarone); Diltiazem has 4 (also Ezetimibe, Simvastatin, Theophylline).
What mechanism field is on file for Ezetimibe/Simvastatin and Diltiazem?
Diltiazem slows down the breakdown of simvastatin in your body, which can lead to higher levels of the drug in your blood. This increases the risk of serious muscle damage.
Ezetimibe/Simvastatin carries more major-labeled pairs than Diltiazem
SPL source-record counts only. This page's band is major · classes on file: Ezetimibe/Simvastatin (Cholesterol Absorption Inhibitor / Statin Combination); Diltiazem (Calcium Channel Blocker).
Ezetimibe/Simvastatin has 8 major-labeled pairs vs Diltiazem's 4.
8 major · 4 moderate · 11 minor · 23 total
- Other major peers for Ezetimibe/Simvastatin
- Amlodipine
- Verapamil
- Cyclosporine
- Amiodarone
4 major · 7 moderate · 35 minor · 46 total
- Other major peers for Diltiazem
- Ezetimibe
- Simvastatin
- Theophylline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.