Niacin and Fluvastatin Interaction
Drug interaction information between Niacin and Fluvastatin.
Niacin and Fluvastatin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Niacin and Fluvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Combining these drugs increases the chance of experiencing muscle pain or damage.
FDA Label Information
Limit fluvastatin dose to 20 mg ( 2.5 , 7.2 ) Concomitant lipid-lowering therapies: Use with fibrates or lipid-modifying doses (≥ 1 g/day) of niacin increases the risk of adverse skeletal muscle effects. 7.5 Niacin The risk of skeletal muscle effects may be enhanced when fluvastatin sodium is used in combination with lipid-modifying doses (≥ 1 g/day) of niacin; a reduction in fluvastatin sodium dosage should be considered in this setting [see Warnings and Precautions ( 5.1 )].
Niacin Also Interacts With
- Atorvastatin moderate
- Ezetimibe moderate
- Ezetimibe/Simvastatin moderate
- Lovastatin moderate
- Pitavastatin moderate
Fluvastatin Also Interacts With
- Clarithromycin major
- Cyclosporine moderate
- Glyburide moderate
- Gemfibrozil moderate
- Phenytoin moderate
Frequently Asked Questions
What SPL severity band is on file for Niacin + Fluvastatin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Niacin has 21 labeled pairs on file vs Fluvastatin's 12. In the moderate band specifically: Niacin has 10 (also Atorvastatin, Ezetimibe, Ezetimibe/Simvastatin, Lovastatin); Fluvastatin has 6 (also Cyclosporine, Glyburide, Gemfibrozil, Phenytoin).
What mechanism field is on file for Niacin and Fluvastatin?
Combining these drugs increases the chance of experiencing muscle pain or damage.
Fluvastatin carries more major-labeled pairs than Niacin
SPL source-record counts only. This page's band is moderate · classes on file: Niacin (Vitamin B3 (Lipid-Modifying)); Fluvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Fluvastatin has 1 major-labeled pair vs Niacin's 0. This page itself is in the moderate band, not the major band.
0 major · 10 moderate · 11 minor · 21 total
- Other moderate peers for Niacin
- Atorvastatin
- Ezetimibe
- Ezetimibe/Simvastatin
- Lovastatin
1 major · 6 moderate · 5 minor · 12 total
- Other moderate peers for Fluvastatin
- Cyclosporine
- Glyburide
- Gemfibrozil
- Phenytoin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.