Niacin and Lovastatin Interaction
Drug interaction information between Niacin and Lovastatin.
Niacin and Lovastatin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Niacin and Lovastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using niacin along with lovastatin increases the risk of serious muscle breakdown and pain.
FDA Label Information
Gemfibrozil Other fibrates Niacin (nicotinic acid) (≥ 1 g/day) Other Drug Interactions Cyclosporine The risk of myopathy/rhabdomyolysis is increased by concomitant administration of cyclosporine (see WARNINGS , Myopathy/Rhabdomyolysis ).
Niacin Also Interacts With
- Atorvastatin moderate
- Ezetimibe moderate
- Ezetimibe/Simvastatin moderate
- Fluvastatin moderate
- Pitavastatin moderate
Lovastatin Also Interacts With
- Darunavir major
- Nirmatrelvir/Ritonavir major
- Spironolactone moderate
- Ketoconazole moderate
- Verapamil moderate
Frequently Asked Questions
What SPL severity band is on file for Niacin + Lovastatin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lovastatin has 30 labeled pairs on file vs Niacin's 21. In the moderate band specifically: Niacin has 10 (also Atorvastatin, Ezetimibe, Ezetimibe/Simvastatin, Fluvastatin); Lovastatin has 17 (also Spironolactone, Ketoconazole, Verapamil, Cyclosporine).
What mechanism field is on file for Niacin and Lovastatin?
Using niacin along with lovastatin increases the risk of serious muscle breakdown and pain.
Lovastatin carries more major-labeled pairs than Niacin
SPL source-record counts only. This page's band is moderate · classes on file: Niacin (Vitamin B3 (Lipid-Modifying)); Lovastatin (HMG-CoA Reductase Inhibitor (Statin)).
Lovastatin has 2 major-labeled pairs vs Niacin's 0. This page itself is in the moderate band, not the major band.
0 major · 10 moderate · 11 minor · 21 total
- Other moderate peers for Niacin
- Atorvastatin
- Ezetimibe
- Ezetimibe/Simvastatin
- Fluvastatin
2 major · 17 moderate · 11 minor · 30 total
- Other moderate peers for Lovastatin
- Spironolactone
- Ketoconazole
- Verapamil
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.