Ezetimibe/Simvastatin and Colchicine Interaction
Drug interaction information between Ezetimibe/Simvastatin and Colchicine.
Ezetimibe/Simvastatin and Colchicine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Ezetimibe/Simvastatin and Colchicine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Combining these medications can increase the risk of developing severe muscle pain and weakness.
FDA Label Information
Colchicine Clinical Impact: Cases of myopathy and rhabdomyolysis have been reported with concomitant use of colchicine with VYTORIN. Intervention: Consider if the benefit of using colchicine concomitantly with VYTORIN outweighs the increased risk of myopathy and rhabdomyolysis.
Ezetimibe/Simvastatin Also Interacts With
- Amlodipine major
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
Colchicine Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Atorvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Ezetimibe/Simvastatin + Colchicine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Colchicine has 28 labeled pairs on file vs Ezetimibe/Simvastatin's 23. In the moderate band specifically: Ezetimibe/Simvastatin has 4 (also Simvastatin, Daptomycin, Niacin); Colchicine has 9 (also Atorvastatin, Ezetimibe, Fenofibrate, Pitavastatin).
What mechanism field is on file for Ezetimibe/Simvastatin and Colchicine?
Combining these medications can increase the risk of developing severe muscle pain and weakness.
Ezetimibe/Simvastatin carries more major-labeled pairs than Colchicine
SPL source-record counts only. This page's band is moderate · classes on file: Ezetimibe/Simvastatin (Cholesterol Absorption Inhibitor / Statin Combination); Colchicine (Anti-Gout Agent).
Ezetimibe/Simvastatin has 8 major-labeled pairs vs Colchicine's 4. This page itself is in the moderate band, not the major band.
8 major · 4 moderate · 11 minor · 23 total
- Other moderate peers for Ezetimibe/Simvastatin
- Simvastatin
- Daptomycin
- Niacin
4 major · 9 moderate · 15 minor · 28 total
- Other moderate peers for Colchicine
- Atorvastatin
- Ezetimibe
- Fenofibrate
- Pitavastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.