Metoprolol and Bupropion Interaction
Drug interaction information between Metoprolol and Bupropion.
Metoprolol and Bupropion have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Metoprolol and Bupropion. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Bupropion blocks a liver enzyme that normally breaks down metoprolol. This causes the amount of metoprolol in your blood to rise to higher levels than expected.
FDA Label Information
( 7.1 ) Drugs metabolized by CYP2D6: Bupropion inhibits CYP2D6 and can increase concentrations of: antidepressants (e.g., venlafaxine, nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, sertraline), antipsychotics (e.g., haloperidol, risperidone, thioridazine), beta-blockers (e.g., metoprolol), and Type 1C antiarrhythmics (e.g., propafenone, flecainide). Such drugs include certain antidepressants (e.g., venlafaxine, nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, and sertraline), antipsychotics (e.g., haloperidol, risperidone, and thioridazine), beta-blockers...
Metoprolol Also Interacts With
- Theophylline major
- Clonidine moderate
- Diltiazem moderate
- Verapamil moderate
- Fluoxetine minor
Bupropion Also Interacts With
- Tranylcypromine major
- Theophylline moderate
- Isavuconazonium moderate
- Sertraline minor
- Fluoxetine minor
Frequently Asked Questions
What SPL severity band is on file for Metoprolol + Bupropion?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Bupropion has 35 labeled pairs on file vs Metoprolol's 18. In the minor band specifically: Metoprolol has 14 (also Fluoxetine, Paroxetine, Propafenone, Epinephrine); Bupropion has 32 (also Sertraline, Fluoxetine, Clopidogrel, Venlafaxine).
What mechanism field is on file for Metoprolol and Bupropion?
Bupropion blocks a liver enzyme that normally breaks down metoprolol. This causes the amount of metoprolol in your blood to rise to higher levels than expected.
Bupropion's labeled portfolio outnumbers Metoprolol
SPL source-record counts only. This page's band is minor · classes on file: Metoprolol (Beta-Blocker); Bupropion (Norepinephrine-Dopamine Reuptake Inhibitor (NDRI)).
1 major · 3 moderate · 14 minor · 18 total
- Other minor peers for Metoprolol
- Fluoxetine
- Paroxetine
- Propafenone
- Epinephrine
1 major · 2 moderate · 32 minor · 35 total
- Other minor peers for Bupropion
- Sertraline
- Fluoxetine
- Clopidogrel
- Venlafaxine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.