Valproate and Risperidone Interaction
Drug interaction information between Valproate and Risperidone.
Valproate and Risperidone have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Valproate and Risperidone. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Risperidone can cause the peak amount of valproate in your blood to increase by a small amount.
What To Do
A dose adjustment for valproate is not typically required when these drugs are used together.
FDA Label Information
Valproate Repeated oral doses of risperidone tablets (4 mg once daily) did not affect the pre-dose or average plasma concentrations and exposure (AUC) of valproate (1000 mg/day in three divided doses) compared to placebo (n=21). However, there was a 20% increase in valproate peak plasma concentration (C max) after concomitant administration of risperidone tablets. Dose adjustment for valproate is not recommended.
Valproate Also Interacts With
- Ranitidine major
- Cimetidine major
- Clarithromycin moderate
- Lidocaine Topical moderate
- Aspirin minor
Risperidone Also Interacts With
- Amitriptyline major
- Carbamazepine major
- Lithium major
- Erythromycin major
- Ranitidine major
Frequently Asked Questions
Can I take Valproate and Risperidone together?
This is a moderate interaction. A dose adjustment for valproate is not typically required when these drugs are used together.
How serious is the interaction between Valproate and Risperidone?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Valproate and Risperidone interact?
Risperidone can cause the peak amount of valproate in your blood to increase by a small amount.
Understanding the Valproate and Risperidone Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Valproate belongs to the Anticonvulsant / Mood Stabilizer class and Risperidone belongs to the Atypical Antipsychotic class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Risperidone can cause the peak amount of valproate in your blood to increase by a small amount. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Valproate has 41 total documented interactions on file in this dataset, and Risperidone has 20. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: A dose adjustment for valproate is not typically required when these drugs are used together. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Valproate or Risperidone based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.