What the FDA labels say about taking them together
Aspirin and valproic acid
Valproic acid's FDA label of January 24, 2025 names aspirin in its drug interactions section; the aspirin label PlainMeds reads does not name valproic acid. The valproic acid label: “… whenever enzyme-inducing or inhibiting drugs are introduced or withdrawn Aspirin, carbapenem antibiotics, estrogen-containing hormonal contraceptives:”
Check it at the source: the aspirin FDA label on DailyMed (effective September 9, 2025); the valproic acid FDA label on DailyMed (effective January 24, 2025, PAI Holdings, LLC dba PAI Pharma).
What does the aspirin label say about valproic acid?
Aspirin's label (effective September 9, 2025) does not name valproic acid in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
What does the valproic acid label say about aspirin?
Valproic acid label, drug interactionsTherefore increased monitoring of valproate and concomitant drug concentrations and dosage adjustment are indicated whenever enzyme-inducing or inhibiting drugs are introduced or withdrawn ( 7.1 ) Aspirin, carbapenem antibiotics, estrogen-containing hormonal contraceptives:
Source: FDA drug label (VALPROIC ACID), PAI Holdings, LLC dba PAI Pharma, effective January 24, 2025 (SPL set 7d5cb52e-37dd-4dfa-a6f4-09f9548846c6), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin | Valproic acid | |
|---|---|---|
| Labeled for | Pain, Cough and cold, Fever | Seizures and epilepsy, Migraine |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0142 per tablet 81 mg tablet | $0.243 per capsule 250 mg capsule |
| Shortage now | A presentation being discontinued | Listed; available |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once