Valproate and Aspirin Interaction
Drug interaction information between Valproate and Aspirin.
Valproate and Aspirin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Valproate and Aspirin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Aspirin can interfere with how the body breaks down valproate, which may cause the levels of the seizure medicine to rise.
FDA Label Information
Therefore increased monitoring of valproate and concomitant drug concentrations and dosage adjustment are indicated whenever enzyme-inducing or inhibiting drugs are introduced or withdrawn ( 7.1 ) • Aspirin, carbapenem antibiotics, estrogen-containing hormonal contraceptives: Monitoring of valproate concentrations is recommended ( 7.1 ) • Co-administration of valproate can affect the pharmacokinetics of other drugs (e.g. Drugs for which a potentially important interaction has been observed Aspirin A study involving the co-administration of aspirin at antipyretic doses (11 to 16 mg/kg) with...
Valproate Also Interacts With
- Ranitidine major
- Cimetidine major
- Clarithromycin moderate
- Lidocaine Topical moderate
- Risperidone moderate
Aspirin Also Interacts With
- Atenolol major
- Fluoxetine major
- Ibandronate major
- Alendronate moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Valproate + Aspirin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aspirin has 47 labeled pairs on file vs Valproate's 41. In the minor band specifically: Valproate has 36 (also Clonazepam, Topiramate, Amitriptyline, Acetaminophen); Aspirin has 32 (also Carisoprodol, Celecoxib, Colestipol, Diflunisal).
What mechanism field is on file for Valproate and Aspirin?
Aspirin can interfere with how the body breaks down valproate, which may cause the levels of the seizure medicine to rise.
Aspirin carries more major-labeled pairs than Valproate
SPL source-record counts only. This page's band is minor · classes on file: Valproate (Anticonvulsant / Mood Stabilizer); Aspirin (Antiplatelet / NSAID).
Aspirin has 3 major-labeled pairs vs Valproate's 2. This page itself is in the minor band, not the major band.
2 major · 3 moderate · 36 minor · 41 total
- Other minor peers for Valproate
- Clonazepam
- Topiramate
- Amitriptyline
- Acetaminophen
3 major · 12 moderate · 32 minor · 47 total
- Other minor peers for Aspirin
- Carisoprodol
- Celecoxib
- Colestipol
- Diflunisal
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.