What the FDA labels say about taking them together
Clonazepam and valproic acid
Valproic acid's FDA label of January 24, 2025 names clonazepam in its drug interactions section; clonazepam's label does not name valproic acid itself but warns about its class (Anti-seizure medicines).
Check it at the source: the clonazepam FDA label on DailyMed (effective December 1, 2025, H2-Pharma, LLC); the valproic acid FDA label on DailyMed (effective January 24, 2025, PAI Holdings, LLC dba PAI Pharma).
What does the clonazepam label say about valproic acid?
Clonazepam's label does not name valproic acid itself; it warns about its class (Anti-seizure medicines):
Clonazepam label, warningsSuicidal Behavior and Ideation Antiepileptic drugs (AEDs), including Klonopin, increase the risk of suicidal thoughts or behavior in patients taking these drugs for any indication.
Clonazepam label, warningsPatients treated with any AED for any indication should be monitored for the emergence or worsening of depression, suicidal thoughts or behavior, and/or any unusual changes in mood or behavior.
Source: FDA drug label (Klonopin), NDA017533 (Cheplapharm), as published by H2-Pharma, LLC, effective December 1, 2025 (SPL set cfa0d79a-843c-4b88-95a1-e9511d649ca1), via openFDA; the full label on DailyMed
What does the valproic acid label say about clonazepam?
Valproic acid label, drug interactionsClonazepam The concomitant use of valproate and clonazepam may induce absence status in patients with a history of absence type seizures.
Source: FDA drug label (VALPROIC ACID), PAI Holdings, LLC dba PAI Pharma, effective January 24, 2025 (SPL set 7d5cb52e-37dd-4dfa-a6f4-09f9548846c6), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clonazepam | Valproic acid | |
|---|---|---|
| Labeled for | Seizures and epilepsy, Anxiety | Seizures and epilepsy, Migraine |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0244 per tablet 1 mg tablet | $0.243 per capsule 250 mg capsule |
| Shortage now | In shortage | Listed; available |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once