Valproate and Clonazepam Interaction
Drug interaction information between Valproate and Clonazepam.
Valproate and Clonazepam have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Valproate and Clonazepam. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Combining these two medications can trigger a long-lasting seizure state called absence status in patients who have had these types of seizures before.
FDA Label Information
Clonazepam The concomitant use of valproate and clonazepam may induce absence status in patients with a history of absence type seizures.
Valproate Also Interacts With
- Ranitidine major
- Cimetidine major
- Clarithromycin moderate
- Lidocaine Topical moderate
- Risperidone moderate
Clonazepam Also Interacts With
- Sertraline major
- Fluoxetine major
- Felbamate major
- Diazepam moderate
- Lamotrigine minor
Frequently Asked Questions
What SPL severity band is on file for Valproate + Clonazepam?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Valproate has 41 labeled pairs on file vs Clonazepam's 14. In the minor band specifically: Valproate has 36 (also Aspirin, Topiramate, Amitriptyline, Acetaminophen); Clonazepam has 10 (also Lamotrigine, Fluconazole, Carbamazepine, Ranitidine).
What mechanism field is on file for Valproate and Clonazepam?
Combining these two medications can trigger a long-lasting seizure state called absence status in patients who have had these types of seizures before.
Clonazepam carries more major-labeled pairs than Valproate
SPL source-record counts only. This page's band is minor · classes on file: Valproate (Anticonvulsant / Mood Stabilizer); Clonazepam (Benzodiazepine).
Clonazepam has 3 major-labeled pairs vs Valproate's 2. This page itself is in the minor band, not the major band.
2 major · 3 moderate · 36 minor · 41 total
- Other minor peers for Valproate
- Aspirin
- Topiramate
- Amitriptyline
- Acetaminophen
3 major · 1 moderate · 10 minor · 14 total
- Other minor peers for Clonazepam
- Lamotrigine
- Fluconazole
- Carbamazepine
- Ranitidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.