What the FDA labels say about taking them together
Ranitidine and valproic acid
Valproic acid's FDA label of January 24, 2025 names ranitidine in its drug interactions section; the ranitidine label PlainMeds reads does not name valproic acid. The valproic acid label: “Cimetidine and Ranitidine Cimetidine and ranitidine do not affect the clearance of valproate.”
Check it at the source: the ranitidine FDA label on DailyMed (effective May 1, 2026, Amneal Pharmaceuticals of New York LLC); the valproic acid FDA label on DailyMed (effective January 24, 2025, PAI Holdings, LLC dba PAI Pharma).
What does the ranitidine label say about valproic acid?
Ranitidine's label (effective May 1, 2026) does not name valproic acid in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Ranitidine), Amneal Pharmaceuticals of New York LLC, effective May 1, 2026 (SPL set b38a3332-5c54-453f-aeb7-070f830955c2), via openFDA; the full label on DailyMed
What does the valproic acid label say about ranitidine?
Valproic acid label, drug interactionsCimetidine and Ranitidine Cimetidine and ranitidine do not affect the clearance of valproate.
Source: FDA drug label (VALPROIC ACID), PAI Holdings, LLC dba PAI Pharma, effective January 24, 2025 (SPL set 7d5cb52e-37dd-4dfa-a6f4-09f9548846c6), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ranitidine | Valproic acid | |
|---|---|---|
| Labeled for | Acid reflux and ulcers | Seizures and epilepsy, Migraine |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.243 per capsule 250 mg capsule |
| Shortage now | No current entry | Listed; available |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once