Codeine · larger labeled portfolio than Acetaminophen
SPL labels Acetaminophen + Codeine as minor; Acetaminophen 21 / Codeine 27 in that band.
Mechanism on file: These two drugs work in different ways to help stop pain better than they would on their own. One works on the brain's pain centers while the other works on different pain signals in the body.
FDA SPL severity: Minor
Acetaminophen + Codeine · SPL mechanism field
These two drugs work in different ways to help stop pain better than they would on their own. One works on the brain's pain centers while the other works on different pain signals in the body.
Minor band excerpt · Acetaminophen with Codeine
Drug Interactions Anticoagulants Chronic oral acetaminophen use at a dose of 4000 mg/day has been shown to cause an increase in international normalized ratio (INR) in some patients who have been stabilized on sodium warfarin as an anticoagulant. As no studies have been performed evaluating the short term use of acetaminophen and codeine phosphate tablets in patients on oral anticoagulants, more frequent assessment of INR may be appropriate in such circumstances. The concomitant use of acetaminophen and codeine phosphate tablets and CYP2D6 inhibitors (e.g., paroxetine, fluoxetine,...
Acetaminophen · 21 minor + 23 total pairs
- Acetaminophen/Oxycodone minor
- Carbamazepine minor
- Cidofovir minor
- Diflunisal minor
Codeine · 27 SPL pairs (broader portfolio than Acetaminophen)
- Alprazolam minor
- Buprenorphine minor
- Bupropion minor
- Butorphanol minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.