Acetaminophen and Cidofovir Interaction
Drug interaction information between Acetaminophen and Cidofovir.
Acetaminophen and Cidofovir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Acetaminophen and Cidofovir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Probenecid is taken alongside cidofovir and can interfere with how your body processes and removes acetaminophen. This could result in higher levels of acetaminophen in your system.
FDA Label Information
Drug Interactions Probenecid Probenecid is known to interact with the metabolism or renal tubular excretion of many drugs (e.g., acetaminophen, acyclovir, angiotensin-converting enzyme inhibitors, aminosalicylic acid, barbiturates, benzodiazepines, bumetanide, clofibrate, methotrexate, famotidine, furosemide, nonsteroidal anti-inflammatory agents, theophylline, and zidovudine).
Acetaminophen Also Interacts With
- Dapsone Topical moderate
- Lidocaine Topical moderate
- Acetaminophen/Oxycodone minor
- Carbamazepine minor
- Codeine minor
Cidofovir Also Interacts With
- Vancomycin major
- Gentamicin major
- Tobramycin major
- Amikacin major
- Amphotericin B major
Frequently Asked Questions
What SPL severity band is on file for Acetaminophen + Cidofovir?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Acetaminophen has 23 labeled pairs on file vs Cidofovir's 16. In the minor band specifically: Acetaminophen has 21 (also Acetaminophen/Oxycodone, Carbamazepine, Codeine, Diflunisal); Cidofovir has 11 (also Furosemide, Famotidine, Methotrexate, Acyclovir).
What mechanism field is on file for Acetaminophen and Cidofovir?
Probenecid is taken alongside cidofovir and can interfere with how your body processes and removes acetaminophen. This could result in higher levels of acetaminophen in your system.
Cidofovir carries more major-labeled pairs than Acetaminophen
SPL source-record counts only. This page's band is minor · classes on file: Acetaminophen (Analgesic / Antipyretic); Cidofovir (Antiviral (Nucleotide Analog)).
Cidofovir has 5 major-labeled pairs vs Acetaminophen's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 21 minor · 23 total
- Other minor peers for Acetaminophen
- Acetaminophen/Oxycodone
- Carbamazepine
- Codeine
- Diflunisal
5 major · 0 moderate · 11 minor · 16 total
- Other minor peers for Cidofovir
- Furosemide
- Famotidine
- Methotrexate
- Acyclovir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.