Acetaminophen and Carbamazepine Interaction
Drug interaction information between Acetaminophen and Carbamazepine.
Acetaminophen and Carbamazepine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Acetaminophen and Carbamazepine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Carbamazepine causes your body to process acetaminophen more quickly, which may prevent it from working well for pain.
FDA Label Information
In addition, carbamazepine causes, or would be expected to cause, decreased levels of the following drugs, for which monitoring of concentrations or dosage adjustment may be necessary: acetaminophen, albendazole, alprazolam, aprepitant, buprenorphone, bupropion, citalopram, clonazepam, clozapine, corticosteroids (e.g., prednisolone, dexamethasone), cyclosporine, dicumarol, dihydropyridine calcium channel blockers (e.g., felodipine), doxycycline, ethosuximide, everolimus, haloperidol, imatinib, itraconazole, lamotrigine, levothyroxine, methadone, methsuximide, mianserin, midazolam,...
Acetaminophen Also Interacts With
- Dapsone Topical moderate
- Lidocaine Topical moderate
- Acetaminophen/Oxycodone minor
- Cidofovir minor
- Codeine minor
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Acetaminophen + Carbamazepine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Acetaminophen's 23. In the minor band specifically: Acetaminophen has 21 (also Acetaminophen/Oxycodone, Cidofovir, Codeine, Diflunisal); Carbamazepine has 110 (also Omeprazole, Ibuprofen, Citalopram, Amitriptyline).
What mechanism field is on file for Acetaminophen and Carbamazepine?
Carbamazepine causes your body to process acetaminophen more quickly, which may prevent it from working well for pain.
Carbamazepine carries more major-labeled pairs than Acetaminophen
SPL source-record counts only. This page's band is minor · classes on file: Acetaminophen (Analgesic / Antipyretic); Carbamazepine (Anticonvulsant).
Carbamazepine has 3 major-labeled pairs vs Acetaminophen's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 21 minor · 23 total
- Other minor peers for Acetaminophen
- Acetaminophen/Oxycodone
- Cidofovir
- Codeine
- Diflunisal
3 major · 16 moderate · 110 minor · 129 total
- Other minor peers for Carbamazepine
- Omeprazole
- Ibuprofen
- Citalopram
- Amitriptyline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.