Acetaminophen and Acetaminophen/Oxycodone Interaction
Drug interaction information between Acetaminophen and Acetaminophen/Oxycodone.
Acetaminophen and Acetaminophen/Oxycodone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Acetaminophen and Acetaminophen/Oxycodone. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Taking both of these medicines at the same time means you are getting the same active ingredient from two different sources, which can lead to a dangerous buildup in your liver.
What To Do
Avoid taking any other products that contain acetaminophen while using this medicine. Check the labels of all over-the-counter drugs to ensure you do not exceed the safe daily limit.
FDA Label Information
Alcohol, ethyl Hepatotoxicity has occurred in chronic alcoholics following various dose levels (moderate to excessive) of acetaminophen. Oral Contraceptives Increase in glucuronidation resulting in increased plasma clearance and a decreased half-life of acetaminophen. Charcoal (activated) Reduces acetaminophen absorption when administered as soon as possible after overdose.
Acetaminophen Also Interacts With
- Dapsone Topical moderate
- Lidocaine Topical moderate
- Carbamazepine minor
- Cidofovir minor
- Codeine minor
Acetaminophen/Oxycodone Also Interacts With
- Gabapentin moderate
- Pregabalin moderate
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
Frequently Asked Questions
Can I take Acetaminophen and Acetaminophen/Oxycodone together?
This is a minor interaction. Avoid taking any other products that contain acetaminophen while using this medicine. Check the labels of all over-the-counter drugs to ensure you do not exceed the safe daily limit.
How serious is the interaction between Acetaminophen and Acetaminophen/Oxycodone?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Acetaminophen and Acetaminophen/Oxycodone interact?
Taking both of these medicines at the same time means you are getting the same active ingredient from two different sources, which can lead to a dangerous buildup in your liver.
Understanding the Acetaminophen and Acetaminophen/Oxycodone Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Acetaminophen belongs to the Analgesic / Antipyretic class and Acetaminophen/Oxycodone belongs to the Opioid Analgesic Combination class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Taking both of these medicines at the same time means you are getting the same active ingredient from two different sources, which can lead to a dangerous buildup in your liver. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Acetaminophen has 23 total documented interactions on file in this dataset, and Acetaminophen/Oxycodone has 23. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Avoid taking any other products that contain acetaminophen while using this medicine. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Acetaminophen or Acetaminophen/Oxycodone based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.