Acetaminophen and Acetaminophen/Oxycodone Interaction
Drug interaction information between Acetaminophen and Acetaminophen/Oxycodone.
Acetaminophen and Acetaminophen/Oxycodone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Acetaminophen and Acetaminophen/Oxycodone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking both of these medicines at the same time means you are getting the same active ingredient from two different sources, which can lead to a dangerous buildup in your liver.
FDA Label Information
Alcohol, ethyl Hepatotoxicity has occurred in chronic alcoholics following various dose levels (moderate to excessive) of acetaminophen. Oral Contraceptives Increase in glucuronidation resulting in increased plasma clearance and a decreased half-life of acetaminophen. Charcoal (activated) Reduces acetaminophen absorption when administered as soon as possible after overdose.
Acetaminophen Also Interacts With
- Dapsone Topical moderate
- Lidocaine Topical moderate
- Carbamazepine minor
- Cidofovir minor
- Codeine minor
Acetaminophen/Oxycodone Also Interacts With
- Gabapentin moderate
- Pregabalin moderate
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
Frequently Asked Questions
What SPL severity band is on file for Acetaminophen + Acetaminophen/Oxycodone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
How many labeled pairs sit in each drug's minor band?
Acetaminophen and Acetaminophen/Oxycodone tie at 23 labeled pairs each. minor-band counts: Acetaminophen 21 alongside Carbamazepine, Cidofovir, Codeine, Diflunisal; Acetaminophen/Oxycodone 21 alongside Trazodone, Tramadol, Cyclobenzaprine, Oxycodone.
What mechanism field is on file for Acetaminophen and Acetaminophen/Oxycodone?
Taking both of these medicines at the same time means you are getting the same active ingredient from two different sources, which can lead to a dangerous buildup in your liver.
Acetaminophen and Acetaminophen/Oxycodone · minor-band peers
SPL source-record counts only. This page's band is minor · classes on file: Acetaminophen (Analgesic / Antipyretic); Acetaminophen/Oxycodone (Opioid Analgesic Combination).
0 major · 2 moderate · 21 minor · 23 total
- Other minor peers for Acetaminophen
- Carbamazepine
- Cidofovir
- Codeine
- Diflunisal
0 major · 2 moderate · 21 minor · 23 total
- Other minor peers for Acetaminophen/Oxycodone
- Trazodone
- Tramadol
- Cyclobenzaprine
- Oxycodone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.