Lurasidone and Valproate Interaction
Drug interaction information between Lurasidone and Valproate.
Lurasidone and Valproate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Lurasidone and Valproate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two medications do not have a significant effect on each other's levels or how they work in the body.
FDA Label Information
Examples: Bosentan, efavirenz, etravirine, modafinil, nafcillin 7.2 Drugs Having No Clinically Important Interactions with Lurasidone Hydrochloride Based on pharmacokinetic studies, no dosage adjustment of lurasidone hydrochloride is required when administered concomitantly with lithium, valproate, or substrates of P-gp or CYP3A4 [see Clinical Pharmacology ( 12.3 )].
Lurasidone Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Voriconazole major
Valproate Also Interacts With
- Ranitidine major
- Cimetidine major
- Clarithromycin moderate
- Lidocaine Topical moderate
- Risperidone moderate
Frequently Asked Questions
What SPL severity band is on file for Lurasidone + Valproate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Valproate has 41 labeled pairs on file vs Lurasidone's 15. In the minor band specifically: Lurasidone has 10 (also Diltiazem, Ketoconazole, Fluconazole, Verapamil); Valproate has 36 (also Aspirin, Clonazepam, Topiramate, Amitriptyline).
What mechanism field is on file for Lurasidone and Valproate?
These two medications do not have a significant effect on each other's levels or how they work in the body.
Lurasidone carries more major-labeled pairs than Valproate
SPL source-record counts only. This page's band is minor · classes on file: Lurasidone (Atypical Antipsychotic); Valproate (Anticonvulsant / Mood Stabilizer).
Lurasidone has 5 major-labeled pairs vs Valproate's 2. This page itself is in the minor band, not the major band.
5 major · 0 moderate · 10 minor · 15 total
- Other minor peers for Lurasidone
- Diltiazem
- Ketoconazole
- Fluconazole
- Verapamil
2 major · 3 moderate · 36 minor · 41 total
- Other minor peers for Valproate
- Aspirin
- Clonazepam
- Topiramate
- Amitriptyline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.