Lurasidone and Itraconazole Interaction
Drug interaction information between Lurasidone and Itraconazole.
Lurasidone and Itraconazole have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Lurasidone and Itraconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole stops the enzymes that process lurasidone, leading to a buildup of the medication in your blood.
FDA Label Information
Lurasidone Midazolam (oral) a Pimozide Triazolam a Contraindicated during and 2 weeks after itraconazole treatment.
Lurasidone Also Interacts With
- Clarithromycin major
- Darunavir major
- Nirmatrelvir/Ritonavir major
- Voriconazole major
- Diltiazem minor
Itraconazole Also Interacts With
- Isavuconazonium major
- Pimozide major
- Methadone major
- Midazolam major
- Felodipine major
Frequently Asked Questions
What SPL severity band is on file for Lurasidone + Itraconazole?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Lurasidone's 15. In the major band specifically: Lurasidone has 5 (also Clarithromycin, Darunavir, Nirmatrelvir/Ritonavir, Voriconazole); Itraconazole has 19 (also Isavuconazonium, Pimozide, Methadone, Midazolam).
What mechanism field is on file for Lurasidone and Itraconazole?
Itraconazole stops the enzymes that process lurasidone, leading to a buildup of the medication in your blood.
Itraconazole carries more major-labeled pairs than Lurasidone
SPL source-record counts only. This page's band is major · classes on file: Lurasidone (Atypical Antipsychotic); Itraconazole (Azole Antifungal).
Itraconazole has 19 major-labeled pairs vs Lurasidone's 5.
5 major · 0 moderate · 10 minor · 15 total
- Other major peers for Lurasidone
- Clarithromycin
- Darunavir
- Nirmatrelvir/Ritonavir
- Voriconazole
19 major · 20 moderate · 77 minor · 116 total
- Other major peers for Itraconazole
- Isavuconazonium
- Pimozide
- Methadone
- Midazolam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.