Lurasidone and Ketoconazole Interaction
Drug interaction information between Lurasidone and Ketoconazole.
Lurasidone and Ketoconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Lurasidone and Ketoconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ketoconazole slows down how your body processes lurasidone, which can cause the drug to build up to higher levels in your body.
FDA Label Information
Examples: Ketoconazole, clarithromycin, ritonavir, voriconazole, mibefradil Moderate CYP3A4 Inhibitors Clinical Impact: Concomitant use of lurasidone hydrochloride with moderate CYP3A4 inhibitors increased the exposure of lurasidone compared to the use of lurasidone hydrochloride alone [see Clinical Pharmacology ( 12.3 )].
Lurasidone Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Voriconazole major
Ketoconazole Also Interacts With
- Alfuzosin major
- Dronedarone major
- Ranolazine major
- Saxagliptin major
- Sildenafil major
Frequently Asked Questions
What SPL severity band is on file for Lurasidone + Ketoconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ketoconazole has 113 labeled pairs on file vs Lurasidone's 15. In the minor band specifically: Lurasidone has 10 (also Diltiazem, Valproate, Fluconazole, Verapamil); Ketoconazole has 85 (also Abiraterone, Acetaminophen/Oxycodone, Alosetron, Amphotericin B).
What mechanism field is on file for Lurasidone and Ketoconazole?
Ketoconazole slows down how your body processes lurasidone, which can cause the drug to build up to higher levels in your body.
Ketoconazole carries more major-labeled pairs than Lurasidone
SPL source-record counts only. This page's band is minor · classes on file: Lurasidone (Atypical Antipsychotic); Ketoconazole (Azole Antifungal).
Ketoconazole has 6 major-labeled pairs vs Lurasidone's 5. This page itself is in the minor band, not the major band.
5 major · 0 moderate · 10 minor · 15 total
- Other minor peers for Lurasidone
- Diltiazem
- Valproate
- Fluconazole
- Verapamil
6 major · 22 moderate · 85 minor · 113 total
- Other minor peers for Ketoconazole
- Abiraterone
- Acetaminophen/Oxycodone
- Alosetron
- Amphotericin B
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.