Lurasidone and Verapamil Interaction
Drug interaction information between Lurasidone and Verapamil.
Lurasidone and Verapamil have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Lurasidone and Verapamil. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Verapamil causes your body to process lurasidone more quickly, leading to lower levels of the drug in your system.
FDA Label Information
Examples: Diltiazem, atazanavir, erythromycin, fluconazole, verapamil Strong CYP3A4 Inducers Clinical Impact: Concomitant use of lurasidone hydrochloride with strong CYP3A4 inducers decreased the exposure of lurasidone compared to the use of lurasidone hydrochloride alone [see Clinical Pharmacology ( 12.3 )].
Lurasidone Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Voriconazole major
Verapamil Also Interacts With
- Eplerenone major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Clarithromycin moderate
Frequently Asked Questions
What SPL severity band is on file for Lurasidone + Verapamil?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Verapamil has 57 labeled pairs on file vs Lurasidone's 15. In the minor band specifically: Lurasidone has 10 (also Diltiazem, Ketoconazole, Valproate, Fluconazole); Verapamil has 47 (also Atorvastatin, Aspirin, Atenolol, Timolol).
What mechanism field is on file for Lurasidone and Verapamil?
Verapamil causes your body to process lurasidone more quickly, leading to lower levels of the drug in your system.
Lurasidone carries more major-labeled pairs than Verapamil
SPL source-record counts only. This page's band is minor · classes on file: Lurasidone (Atypical Antipsychotic); Verapamil (Calcium Channel Blocker).
Lurasidone has 5 major-labeled pairs vs Verapamil's 4. This page itself is in the minor band, not the major band.
5 major · 0 moderate · 10 minor · 15 total
- Other minor peers for Lurasidone
- Diltiazem
- Ketoconazole
- Valproate
- Fluconazole
4 major · 6 moderate · 47 minor · 57 total
- Other minor peers for Verapamil
- Atorvastatin
- Aspirin
- Atenolol
- Timolol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.