Lurasidone and Darunavir Interaction
Drug interaction information between Lurasidone and Darunavir.
Lurasidone and Darunavir have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Lurasidone and Darunavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir causes lurasidone to build up in the body to unsafe levels.
FDA Label Information
Antipsychotics: lurasidone ↑ lurasidone Co-administration is contraindicated due to potential for serious and/or life-threatening reactions.
Lurasidone Also Interacts With
- Clarithromycin major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Voriconazole major
- Diltiazem minor
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Pimozide major
- Midazolam major
- Dronedarone major
Frequently Asked Questions
What SPL severity band is on file for Lurasidone + Darunavir?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Lurasidone's 15. In the major band specifically: Lurasidone has 5 (also Clarithromycin, Itraconazole, Nirmatrelvir/Ritonavir, Voriconazole); Darunavir has 15 (also Lovastatin, Sildenafil, Pimozide, Midazolam).
What mechanism field is on file for Lurasidone and Darunavir?
Darunavir causes lurasidone to build up in the body to unsafe levels.
Darunavir carries more major-labeled pairs than Lurasidone
SPL source-record counts only. This page's band is major · classes on file: Lurasidone (Atypical Antipsychotic); Darunavir (HIV Protease Inhibitor).
Darunavir has 15 major-labeled pairs vs Lurasidone's 5.
5 major · 0 moderate · 10 minor · 15 total
- Other major peers for Lurasidone
- Clarithromycin
- Itraconazole
- Nirmatrelvir/Ritonavir
- Voriconazole
15 major · 16 moderate · 70 minor · 101 total
- Other major peers for Darunavir
- Lovastatin
- Sildenafil
- Pimozide
- Midazolam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.