Lurasidone and Voriconazole Interaction
Drug interaction information between Lurasidone and Voriconazole.
Lurasidone and Voriconazole have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Lurasidone and Voriconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Voriconazole blocks the enzyme that normally clears lurasidone from your system. This can cause lurasidone to build up to unsafe levels in your body, increasing the risk of toxic effects.
FDA Label Information
Ergot Alkaloids (CYP450 Inhibition) Not Studied In Vivo or In Vitro , but Drug Plasma Exposure Likely to be Increased Contraindicated Naloxegol (CYP3A4 Inhibition) Not Studied In Vivo or In Vitro , but Drug Plasma Exposure Likely to be Increased which may Increase the Risk of Adverse Reactions Contraindicated Tolvaptan (CYP3A4 Inhibition) Although Not Studied Clinically, Voriconazole is Likely to Significantly Increase the Plasma Concentrations of Tolvaptan Contraindicated Lurasidone (CYP3A4 Inhibition) Not Studied In Vivo or In Vitro , but Voriconazole is Likely to Significantly Increase...
Lurasidone Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Diltiazem minor
Voriconazole Also Interacts With
- Norethindrone major
- Rifampin major
- Pimozide major
- Ivabradine major
- Phenytoin major
Frequently Asked Questions
What SPL severity band is on file for Lurasidone + Voriconazole?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Voriconazole has 50 labeled pairs on file vs Lurasidone's 15. In the major band specifically: Lurasidone has 5 (also Clarithromycin, Darunavir, Itraconazole, Nirmatrelvir/Ritonavir); Voriconazole has 8 (also Norethindrone, Rifampin, Pimozide, Ivabradine).
What mechanism field is on file for Lurasidone and Voriconazole?
Voriconazole blocks the enzyme that normally clears lurasidone from your system. This can cause lurasidone to build up to unsafe levels in your body, increasing the risk of toxic effects.
Voriconazole carries more major-labeled pairs than Lurasidone
SPL source-record counts only. This page's band is major · classes on file: Lurasidone (Atypical Antipsychotic); Voriconazole (Azole Antifungal).
Voriconazole has 8 major-labeled pairs vs Lurasidone's 5.
5 major · 0 moderate · 10 minor · 15 total
- Other major peers for Lurasidone
- Clarithromycin
- Darunavir
- Itraconazole
- Nirmatrelvir/Ritonavir
8 major · 9 moderate · 33 minor · 50 total
- Other major peers for Voriconazole
- Norethindrone
- Rifampin
- Pimozide
- Ivabradine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.