Lurasidone and Voriconazole Interaction
Drug interaction information between Lurasidone and Voriconazole.
Lurasidone and Voriconazole have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Lurasidone and Voriconazole. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Voriconazole blocks the enzyme that normally clears lurasidone from your system. This can cause lurasidone to build up to unsafe levels in your body, increasing the risk of toxic effects.
What To Do
This combination is considered unsafe and should be avoided. Talk to your healthcare provider about using a different medication.
FDA Label Information
Ergot Alkaloids (CYP450 Inhibition) Not Studied In Vivo or In Vitro , but Drug Plasma Exposure Likely to be Increased Contraindicated Naloxegol (CYP3A4 Inhibition) Not Studied In Vivo or In Vitro , but Drug Plasma Exposure Likely to be Increased which may Increase the Risk of Adverse Reactions Contraindicated Tolvaptan (CYP3A4 Inhibition) Although Not Studied Clinically, Voriconazole is Likely to Significantly Increase the Plasma Concentrations of Tolvaptan Contraindicated Lurasidone (CYP3A4 Inhibition) Not Studied In Vivo or In Vitro , but Voriconazole is Likely to Significantly Increase...
Lurasidone Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Diltiazem minor
Voriconazole Also Interacts With
- Norethindrone major
- Rifampin major
- Pimozide major
- Ivabradine major
- Phenytoin major
Frequently Asked Questions
Can I take Lurasidone and Voriconazole together?
This is a major interaction. This combination is considered unsafe and should be avoided. Talk to your healthcare provider about using a different medication.
How serious is the interaction between Lurasidone and Voriconazole?
This interaction is classified as "major" severity by the FDA. Major interactions may be life-threatening or cause serious side effects.
Why do Lurasidone and Voriconazole interact?
Voriconazole blocks the enzyme that normally clears lurasidone from your system. This can cause lurasidone to build up to unsafe levels in your body, increasing the risk of toxic effects.
Understanding the Lurasidone and Voriconazole Interaction
FDA-approved prescribing information for these two drugs flags their combination as a major-severity interaction. Lurasidone belongs to the Atypical Antipsychotic class and Voriconazole belongs to the Azole Antifungal class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Voriconazole blocks the enzyme that normally clears lurasidone from your system. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Lurasidone has 15 total documented interactions on file in this dataset, and Voriconazole has 50. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: This combination is considered unsafe and should be avoided. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Lurasidone or Voriconazole based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.