Lurasidone and Nirmatrelvir/Ritonavir Interaction
Drug interaction information between Lurasidone and Nirmatrelvir/Ritonavir.
Lurasidone and Nirmatrelvir/Ritonavir have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Lurasidone and Nirmatrelvir/Ritonavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Nirmatrelvir/ritonavir slows down the body's ability to clear lurasidone, causing it to build up to dangerous levels. This increase can lead to serious or life-threatening heart rhythm problems.
FDA Label Information
Antipsychotics lurasidone, pimozide ↑ lurasidone ↑ pimozide Co-administration contraindicated due to serious and/or life-threatening reactions such as cardiac arrhythmias [see Contraindications (4) ] .
Lurasidone Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Voriconazole major
- Diltiazem minor
Nirmatrelvir/Ritonavir Also Interacts With
- Simvastatin major
- Lovastatin major
- Sildenafil major
- Carbamazepine major
- Rifampin major
Frequently Asked Questions
What SPL severity band is on file for Lurasidone + Nirmatrelvir/Ritonavir?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Nirmatrelvir/Ritonavir has 86 labeled pairs on file vs Lurasidone's 15. In the major band specifically: Lurasidone has 5 (also Clarithromycin, Darunavir, Itraconazole, Voriconazole); Nirmatrelvir/Ritonavir has 23 (also Simvastatin, Lovastatin, Sildenafil, Carbamazepine).
What mechanism field is on file for Lurasidone and Nirmatrelvir/Ritonavir?
Nirmatrelvir/ritonavir slows down the body's ability to clear lurasidone, causing it to build up to dangerous levels. This increase can lead to serious or life-threatening heart rhythm problems.
Nirmatrelvir/Ritonavir carries more major-labeled pairs than Lurasidone
SPL source-record counts only. This page's band is major · classes on file: Lurasidone (Atypical Antipsychotic); Nirmatrelvir/Ritonavir (Antiviral (Protease Inhibitor Combination)).
Nirmatrelvir/Ritonavir has 23 major-labeled pairs vs Lurasidone's 5.
5 major · 0 moderate · 10 minor · 15 total
- Other major peers for Lurasidone
- Clarithromycin
- Darunavir
- Itraconazole
- Voriconazole
23 major · 30 moderate · 33 minor · 86 total
- Other major peers for Nirmatrelvir/Ritonavir
- Simvastatin
- Lovastatin
- Sildenafil
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.