lurasidone vs valproate
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Side-by-side comparison of lurasidone and valproate. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Examples: Bosentan, efavirenz, etravirine, modafinil, nafcillin 7.2 Drugs Having No Clinically Important Interactions with Lurasidone Hydrochloride Based on pharmacokinetic studies, no dosage adjustment of lurasidone hydrochloride is required when administered concomitantly with lithium, valproate, or substrates of P-gp or CYP3A4 [see Clinical Pharmacology ( 12.3 )].
Latuda
Depakote, Depakene
Lurasidone (Latuda) is a medicine used to treat schizophrenia and bipolar depression. It helps to balance chemicals in the brain.
Valproate sodium injection is used when you cannot take valproate pills. It helps control seizures.
Lurasidone is used to treat schizophrenia in adults and teens ages 13-17. It also treats the depressive phase of bipolar disorder in adults and children ages 10-17. In adults, it can be used alone or with lithium or valproate for bipolar depression.
This medicine treats certain types of seizures. It can be used alone or with other medicines to treat complex partial seizures. It also treats simple and complex absence seizures, and multiple seizure types that include absence seizures.
Lurasidone is an atypical antipsychotic. It works by affecting certain chemicals in the brain, such as dopamine and serotonin. This helps to improve mood, thinking, and behavior.
Valproate affects the levels of certain chemicals in your brain. These chemicals help to control seizures. This medicine helps to reduce the frequency of seizures.
- • Feeling sleepy
- • Feeling restless and needing to move
- • Nausea
- • Weight gain
- • Trouble sleeping
- • Headache
- • Dizziness
- • Nausea
- • Pain at the injection site
- Anxiety 1,223
- Feeling Abnormal 1,166
- Depression 1,120
- Weight Increased 1,077
- Somnolence 1,066
- Drug Interaction 1,185
- Foetal Exposure During Pregnancy 1,043
- Somnolence 950
- Epilepsy 813
- Toxicity To Various Agents 757
This medicine has two important warnings: * **Increased risk of death in elderly people with dementia:** If you are an older adult with dementia-related psychosis, this medicine may increase your chance of death. Lurasidone is not approved for this condition. * **Increased risk of suicidal thoughts and behaviors:** Antidepressants may increase the risk of suicidal thoughts and behaviors in children, teens, and young adults. Your doctor will need to watch you closely for worsening mood or suicidal thoughts.
Valproate can cause life-threatening liver problems, especially in the first 6 months of treatment. Children under 2 and people with mitochondrial disorders have a higher risk. Valproate can also harm an unborn baby, causing birth defects and lower IQ. It can also cause pancreatitis, which can be fatal.
Tell your doctor if you are pregnant or plan to become pregnant. Babies born to mothers who take this medicine in the last 3 months of pregnancy may have withdrawal symptoms or other problems after birth. Talk to your doctor about the risks and benefits of taking lurasidone during pregnancy.
Valproate can cause serious birth defects if taken during pregnancy. Do not take this medicine if you are pregnant or plan to become pregnant unless other medicines don't work for you. There is a pregnancy registry for women who take valproate during pregnancy; call 1-888-233-2334 to enroll.
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How to Read This lurasidone vs valproate Comparison
lurasidone is classified in the Atypical Antipsychotic drug class, while valproate sits within the Anticonvulsant / Mood Stabilizer class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, lurasidone has 5,652 submissions while valproate has 4,748. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to these two medications do not have a significant effect on each other's levels or how they work in the body.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for lurasidone or valproate.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.