Lurasidone and Diltiazem Interaction
Drug interaction information between Lurasidone and Diltiazem.
Lurasidone and Diltiazem have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Lurasidone and Diltiazem. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This combination can cause your body to break down lurasidone too quickly, leading to lower levels of the medicine in your blood.
FDA Label Information
Examples: Diltiazem, atazanavir, erythromycin, fluconazole, verapamil Strong CYP3A4 Inducers Clinical Impact: Concomitant use of lurasidone hydrochloride with strong CYP3A4 inducers decreased the exposure of lurasidone compared to the use of lurasidone hydrochloride alone [see Clinical Pharmacology ( 12.3 )].
Lurasidone Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Voriconazole major
Diltiazem Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Theophylline major
- Rifampin moderate
Frequently Asked Questions
What SPL severity band is on file for Lurasidone + Diltiazem?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Diltiazem has 46 labeled pairs on file vs Lurasidone's 15. In the minor band specifically: Lurasidone has 10 (also Ketoconazole, Valproate, Fluconazole, Verapamil); Diltiazem has 35 (also Buspirone, Pravastatin, Lovastatin, Cyclosporine).
What mechanism field is on file for Lurasidone and Diltiazem?
This combination can cause your body to break down lurasidone too quickly, leading to lower levels of the medicine in your blood.
Lurasidone carries more major-labeled pairs than Diltiazem
SPL source-record counts only. This page's band is minor · classes on file: Lurasidone (Atypical Antipsychotic); Diltiazem (Calcium Channel Blocker).
Lurasidone has 5 major-labeled pairs vs Diltiazem's 4. This page itself is in the minor band, not the major band.
5 major · 0 moderate · 10 minor · 15 total
- Other minor peers for Lurasidone
- Ketoconazole
- Valproate
- Fluconazole
- Verapamil
4 major · 7 moderate · 35 minor · 46 total
- Other minor peers for Diltiazem
- Buspirone
- Pravastatin
- Lovastatin
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.