Lorazepam and Clarithromycin Interaction
Drug interaction information between Lorazepam and Clarithromycin.
Lorazepam and Clarithromycin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Lorazepam and Clarithromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Lorazepam is processed by the body in a way that is not affected by clarithromycin. Because of this, these two drugs are not expected to interfere with each other.
FDA Label Information
Temazepam Nitrazepam Lorazepam No Dose Adjustment Temazepam, Nitrazepam, Lorazepam: For benzodiazepines which are not metabolized by CYP3A (e.g., temazepam, nitrazepam, lorazepam), a clinically important interaction with clarithromycin is unlikely.
Lorazepam Also Interacts With
- Valproate minor
- Clozapine minor
- Probenecid minor
- Theophylline minor
- Aripiprazole minor
Clarithromycin Also Interacts With
- Quetiapine major
- Pioglitazone major
- Fluconazole major
- Cyclosporine major
- Lurasidone major
Frequently Asked Questions
What SPL severity band is on file for Lorazepam + Clarithromycin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clarithromycin has 81 labeled pairs on file vs Lorazepam's 11. In the minor band specifically: Lorazepam has 11 (also Valproate, Clozapine, Probenecid, Theophylline); Clarithromycin has 30 (also Amlodipine, Diltiazem, Erythromycin, Temazepam).
What mechanism field is on file for Lorazepam and Clarithromycin?
Lorazepam is processed by the body in a way that is not affected by clarithromycin. Because of this, these two drugs are not expected to interfere with each other.
Clarithromycin carries more major-labeled pairs than Lorazepam
SPL source-record counts only. This page's band is minor · classes on file: Lorazepam (Benzodiazepine); Clarithromycin (Macrolide Antibiotic).
Clarithromycin has 16 major-labeled pairs vs Lorazepam's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 11 minor · 11 total
- Other minor peers for Lorazepam
- Valproate
- Clozapine
- Probenecid
- Theophylline
16 major · 35 moderate · 30 minor · 81 total
- Other minor peers for Clarithromycin
- Amlodipine
- Diltiazem
- Erythromycin
- Temazepam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.