Lorazepam and Clarithromycin Interaction
Drug interaction information between Lorazepam and Clarithromycin.
Lorazepam and Clarithromycin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Lorazepam and Clarithromycin. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Lorazepam is processed by the body in a way that is not affected by clarithromycin. Because of this, these two drugs are not expected to interfere with each other.
What To Do
No special dose changes are usually needed for this combination. You can take these medications together as prescribed by your doctor.
FDA Label Information
Temazepam Nitrazepam Lorazepam No Dose Adjustment Temazepam, Nitrazepam, Lorazepam: For benzodiazepines which are not metabolized by CYP3A (e.g., temazepam, nitrazepam, lorazepam), a clinically important interaction with clarithromycin is unlikely.
Lorazepam Also Interacts With
- Valproate minor
- Clozapine minor
- Probenecid minor
- Theophylline minor
- Aripiprazole minor
Clarithromycin Also Interacts With
- Quetiapine major
- Pioglitazone major
- Fluconazole major
- Cyclosporine major
- Lurasidone major
Frequently Asked Questions
Can I take Lorazepam and Clarithromycin together?
This is a minor interaction. No special dose changes are usually needed for this combination. You can take these medications together as prescribed by your doctor.
How serious is the interaction between Lorazepam and Clarithromycin?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Lorazepam and Clarithromycin interact?
Lorazepam is processed by the body in a way that is not affected by clarithromycin. Because of this, these two drugs are not expected to interfere with each other.
Understanding the Lorazepam and Clarithromycin Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Lorazepam belongs to the Benzodiazepine class and Clarithromycin belongs to the Macrolide Antibiotic class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Lorazepam is processed by the body in a way that is not affected by clarithromycin. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Lorazepam has 11 total documented interactions on file in this dataset, and Clarithromycin has 81. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: No special dose changes are usually needed for this combination. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Lorazepam or Clarithromycin based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.