Clarithromycin and Temazepam Interaction
Drug interaction information between Clarithromycin and Temazepam.
Clarithromycin and Temazepam have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Clarithromycin and Temazepam. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two drugs do not interfere with each other because temazepam is not broken down by the same liver process that clarithromycin affects.
FDA Label Information
Temazepam Nitrazepam Lorazepam No Dose Adjustment Temazepam, Nitrazepam, Lorazepam: For benzodiazepines which are not metabolized by CYP3A (e.g., temazepam, nitrazepam, lorazepam), a clinically important interaction with clarithromycin is unlikely.
Clarithromycin Also Interacts With
- Quetiapine major
- Pioglitazone major
- Fluconazole major
- Cyclosporine major
- Lurasidone major
Temazepam Also Interacts With
- Duloxetine minor
- Estradiol minor
- Ethinyl Estradiol/Etonogestrel minor
- Ethinyl Estradiol/Norgestimate minor
- Etonogestrel minor
Frequently Asked Questions
What SPL severity band is on file for Clarithromycin + Temazepam?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clarithromycin has 81 labeled pairs on file vs Temazepam's 7. In the minor band specifically: Clarithromycin has 30 (also Amlodipine, Lorazepam, Diltiazem, Erythromycin); Temazepam has 7 (also Duloxetine, Estradiol, Ethinyl Estradiol, Ethinyl Estradiol).
What mechanism field is on file for Clarithromycin and Temazepam?
These two drugs do not interfere with each other because temazepam is not broken down by the same liver process that clarithromycin affects.
Clarithromycin carries more major-labeled pairs than Temazepam
SPL source-record counts only. This page's band is minor · classes on file: Clarithromycin (Macrolide Antibiotic); Temazepam (Benzodiazepine (Hypnotic)).
Clarithromycin has 16 major-labeled pairs vs Temazepam's 0. This page itself is in the minor band, not the major band.
16 major · 35 moderate · 30 minor · 81 total
- Other minor peers for Clarithromycin
- Amlodipine
- Lorazepam
- Diltiazem
- Erythromycin
0 major · 0 moderate · 7 minor · 7 total
- Other minor peers for Temazepam
- Duloxetine
- Estradiol
- Ethinyl Estradiol
- Ethinyl Estradiol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.