Clarithromycin and Diltiazem Interaction
Drug interaction information between Clarithromycin and Diltiazem.
Clarithromycin and Diltiazem have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Clarithromycin and Diltiazem. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clarithromycin interferes with how your body processes diltiazem by blocking certain enzymes. This can lead to higher levels of diltiazem in your blood, which may affect your heart rate.
FDA Label Information
Amlodipine Diltiazem Amlodipine, Diltiazem: [See Warnings and Precautions ( 5.4 )] Nifedipine Nifedipine: Nifedipine is a substrate for CYP3A.
Clarithromycin Also Interacts With
- Quetiapine major
- Pioglitazone major
- Fluconazole major
- Cyclosporine major
- Lurasidone major
Diltiazem Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Theophylline major
- Rifampin moderate
Frequently Asked Questions
What SPL severity band is on file for Clarithromycin + Diltiazem?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clarithromycin has 81 labeled pairs on file vs Diltiazem's 46. In the minor band specifically: Clarithromycin has 30 (also Amlodipine, Lorazepam, Erythromycin, Temazepam); Diltiazem has 35 (also Buspirone, Pravastatin, Lovastatin, Cyclosporine).
What mechanism field is on file for Clarithromycin and Diltiazem?
Clarithromycin interferes with how your body processes diltiazem by blocking certain enzymes. This can lead to higher levels of diltiazem in your blood, which may affect your heart rate.
Clarithromycin carries more major-labeled pairs than Diltiazem
SPL source-record counts only. This page's band is minor · classes on file: Clarithromycin (Macrolide Antibiotic); Diltiazem (Calcium Channel Blocker).
Clarithromycin has 16 major-labeled pairs vs Diltiazem's 4. This page itself is in the minor band, not the major band.
16 major · 35 moderate · 30 minor · 81 total
- Other minor peers for Clarithromycin
- Amlodipine
- Lorazepam
- Erythromycin
- Temazepam
4 major · 7 moderate · 35 minor · 46 total
- Other minor peers for Diltiazem
- Buspirone
- Pravastatin
- Lovastatin
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.