Lefamulin and Diltiazem Interaction
Drug interaction information between Lefamulin and Diltiazem.
Lefamulin and Diltiazem have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Lefamulin and Diltiazem. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Lefamulin can increase the amount of diltiazem in your body by slowing its breakdown. This makes it more likely that you will experience side effects from the blood pressure medicine.
FDA Label Information
Concomitant use of sensitive CYP3A substrates with XENLETA Tablets requires close monitoring for adverse effects of these drugs (for example, alprazolam, diltiazem, verapamil, simvastatin, vardenafil).
Lefamulin Also Interacts With
- Moxifloxacin moderate
- Erythromycin moderate
- Simvastatin minor
- Alprazolam minor
- Verapamil minor
Diltiazem Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Theophylline major
- Rifampin moderate
Frequently Asked Questions
What SPL severity band is on file for Lefamulin + Diltiazem?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Diltiazem has 46 labeled pairs on file vs Lefamulin's 7. In the minor band specifically: Lefamulin has 5 (also Simvastatin, Alprazolam, Verapamil, Midazolam); Diltiazem has 35 (also Buspirone, Pravastatin, Lovastatin, Cyclosporine).
What mechanism field is on file for Lefamulin and Diltiazem?
Lefamulin can increase the amount of diltiazem in your body by slowing its breakdown. This makes it more likely that you will experience side effects from the blood pressure medicine.
Diltiazem carries more major-labeled pairs than Lefamulin
SPL source-record counts only. This page's band is minor · classes on file: Lefamulin (Pleuromutilin Antibiotic); Diltiazem (Calcium Channel Blocker).
Diltiazem has 4 major-labeled pairs vs Lefamulin's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 5 minor · 7 total
- Other minor peers for Lefamulin
- Simvastatin
- Alprazolam
- Verapamil
- Midazolam
4 major · 7 moderate · 35 minor · 46 total
- Other minor peers for Diltiazem
- Buspirone
- Pravastatin
- Lovastatin
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.