Lefamulin and Simvastatin Interaction
Drug interaction information between Lefamulin and Simvastatin.
Lefamulin and Simvastatin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Lefamulin and Simvastatin. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Lefamulin can slow down how your body breaks down simvastatin. This may cause the cholesterol medicine to build up in your blood and increase the risk of side effects.
What To Do
Your doctor should watch you closely for side effects while you are taking both medicines. Tell your healthcare provider if you have any new muscle pain or weakness.
FDA Label Information
Concomitant use of sensitive CYP3A substrates with XENLETA Tablets requires close monitoring for adverse effects of these drugs (for example, alprazolam, diltiazem, verapamil, simvastatin, vardenafil).
Lefamulin Also Interacts With
- Moxifloxacin moderate
- Erythromycin moderate
- Alprazolam minor
- Diltiazem minor
- Verapamil minor
Simvastatin Also Interacts With
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
- Dronedarone major
Frequently Asked Questions
Can I take Lefamulin and Simvastatin together?
This is a minor interaction. Your doctor should watch you closely for side effects while you are taking both medicines. Tell your healthcare provider if you have any new muscle pain or weakness.
How serious is the interaction between Lefamulin and Simvastatin?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Lefamulin and Simvastatin interact?
Lefamulin can slow down how your body breaks down simvastatin. This may cause the cholesterol medicine to build up in your blood and increase the risk of side effects.
Understanding the Lefamulin and Simvastatin Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Lefamulin belongs to the Pleuromutilin Antibiotic class and Simvastatin belongs to the HMG-CoA Reductase Inhibitor (Statin) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Lefamulin can slow down how your body breaks down simvastatin. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Lefamulin has 7 total documented interactions on file in this dataset, and Simvastatin has 41. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should watch you closely for side effects while you are taking both medicines. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Lefamulin or Simvastatin based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.