Lefamulin and Moxifloxacin Interaction
Drug interaction information between Lefamulin and Moxifloxacin.
Lefamulin and Moxifloxacin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Lefamulin and Moxifloxacin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medicines can affect the electrical timing of your heart. Taking them together increases the risk of developing a life-threatening irregular heartbeat.
FDA Label Information
Therefore, avoid concomitant use of XENLETA Injection and XENLETA Tablets with such drugs (for example, Class IA and III antiarrhythmics, antipsychotics, erythromycin, moxifloxacin, tricyclic antidepressants).
Lefamulin Also Interacts With
- Erythromycin moderate
- Simvastatin minor
- Alprazolam minor
- Diltiazem minor
- Verapamil minor
Moxifloxacin Also Interacts With
- Warfarin minor
- Sotalol minor
- Sucralfate minor
- Zinc Sulfate minor
- Clozapine minor
Frequently Asked Questions
What SPL severity band is on file for Lefamulin + Moxifloxacin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Moxifloxacin has 10 labeled pairs on file vs Lefamulin's 7. In the moderate band specifically: Lefamulin has 2 (also Erythromycin); Moxifloxacin has 1.
What mechanism field is on file for Lefamulin and Moxifloxacin?
Both of these medicines can affect the electrical timing of your heart. Taking them together increases the risk of developing a life-threatening irregular heartbeat.
Moxifloxacin's labeled portfolio outnumbers Lefamulin
SPL source-record counts only. This page's band is moderate · classes on file: Lefamulin (Pleuromutilin Antibiotic); Moxifloxacin (Fluoroquinolone Antibiotic).
0 major · 1 moderate · 9 minor · 10 total
Moxifloxacin has no other moderate-band peer in this dataset besides Lefamulin.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.