Lefamulin and Alprazolam Interaction
Drug interaction information between Lefamulin and Alprazolam.
Lefamulin and Alprazolam have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Lefamulin and Alprazolam. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Lefamulin may interfere with the way your body removes alprazolam. This can lead to higher levels of the anxiety medicine in your system and cause more side effects.
FDA Label Information
Concomitant use of sensitive CYP3A substrates with XENLETA Tablets requires close monitoring for adverse effects of these drugs (for example, alprazolam, diltiazem, verapamil, simvastatin, vardenafil).
Lefamulin Also Interacts With
- Moxifloxacin moderate
- Erythromycin moderate
- Simvastatin minor
- Diltiazem minor
- Verapamil minor
Alprazolam Also Interacts With
- Ketoconazole moderate
- Clarithromycin moderate
- Itraconazole moderate
- Digoxin moderate
- Aprepitant moderate
Frequently Asked Questions
What SPL severity band is on file for Lefamulin + Alprazolam?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Alprazolam has 27 labeled pairs on file vs Lefamulin's 7. In the minor band specifically: Lefamulin has 5 (also Simvastatin, Diltiazem, Verapamil, Midazolam); Alprazolam has 20 (also Tramadol, Oxycodone, Morphine, Carbamazepine).
What mechanism field is on file for Lefamulin and Alprazolam?
Lefamulin may interfere with the way your body removes alprazolam. This can lead to higher levels of the anxiety medicine in your system and cause more side effects.
Alprazolam's labeled portfolio outnumbers Lefamulin
SPL source-record counts only. This page's band is minor · classes on file: Lefamulin (Pleuromutilin Antibiotic); Alprazolam (Benzodiazepine).
0 major · 2 moderate · 5 minor · 7 total
- Other minor peers for Lefamulin
- Simvastatin
- Diltiazem
- Verapamil
- Midazolam
0 major · 7 moderate · 20 minor · 27 total
- Other minor peers for Alprazolam
- Tramadol
- Oxycodone
- Morphine
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.