Lefamulin and Alprazolam Interaction
Drug interaction information between Lefamulin and Alprazolam.
Lefamulin and Alprazolam have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Lefamulin and Alprazolam. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Lefamulin may interfere with the way your body removes alprazolam. This can lead to higher levels of the anxiety medicine in your system and cause more side effects.
What To Do
Your healthcare provider should monitor you closely for increased side effects like extreme sleepiness. Your doctor may need to adjust your dose.
FDA Label Information
Concomitant use of sensitive CYP3A substrates with XENLETA Tablets requires close monitoring for adverse effects of these drugs (for example, alprazolam, diltiazem, verapamil, simvastatin, vardenafil).
Lefamulin Also Interacts With
- Moxifloxacin moderate
- Erythromycin moderate
- Simvastatin minor
- Diltiazem minor
- Verapamil minor
Alprazolam Also Interacts With
- Ketoconazole moderate
- Clarithromycin moderate
- Itraconazole moderate
- Digoxin moderate
- Aprepitant moderate
Frequently Asked Questions
Can I take Lefamulin and Alprazolam together?
This is a minor interaction. Your healthcare provider should monitor you closely for increased side effects like extreme sleepiness. Your doctor may need to adjust your dose.
How serious is the interaction between Lefamulin and Alprazolam?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Lefamulin and Alprazolam interact?
Lefamulin may interfere with the way your body removes alprazolam. This can lead to higher levels of the anxiety medicine in your system and cause more side effects.
Understanding the Lefamulin and Alprazolam Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Lefamulin belongs to the Pleuromutilin Antibiotic class and Alprazolam belongs to the Benzodiazepine class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Lefamulin may interfere with the way your body removes alprazolam. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Lefamulin has 7 total documented interactions on file in this dataset, and Alprazolam has 27. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your healthcare provider should monitor you closely for increased side effects like extreme sleepiness. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Lefamulin or Alprazolam based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.