Lefamulin and Midazolam Interaction
Drug interaction information between Lefamulin and Midazolam.
Lefamulin and Midazolam have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Lefamulin and Midazolam. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Lefamulin affects the way your body processes midazolam, which could cause the drug to build up and increase the risk of side effects.
FDA Label Information
( 4.2 , 7.2 ) Midazolam and other sensitive CYP3A substrates Monitor for adverse reactions.
Lefamulin Also Interacts With
- Moxifloxacin moderate
- Erythromycin moderate
- Simvastatin minor
- Alprazolam minor
- Diltiazem minor
Midazolam Also Interacts With
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Ketoconazole moderate
- Verapamil moderate
Frequently Asked Questions
What SPL severity band is on file for Lefamulin + Midazolam?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Midazolam has 39 labeled pairs on file vs Lefamulin's 7. In the minor band specifically: Lefamulin has 5 (also Simvastatin, Alprazolam, Diltiazem, Verapamil); Midazolam has 27 (also Hydroxyzine, Nifedipine, Morphine, Diazepam).
What mechanism field is on file for Lefamulin and Midazolam?
Lefamulin affects the way your body processes midazolam, which could cause the drug to build up and increase the risk of side effects.
Midazolam carries more major-labeled pairs than Lefamulin
SPL source-record counts only. This page's band is minor · classes on file: Lefamulin (Pleuromutilin Antibiotic); Midazolam (Benzodiazepine).
Midazolam has 3 major-labeled pairs vs Lefamulin's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 5 minor · 7 total
- Other minor peers for Lefamulin
- Simvastatin
- Alprazolam
- Diltiazem
- Verapamil
3 major · 9 moderate · 27 minor · 39 total
- Other minor peers for Midazolam
- Hydroxyzine
- Nifedipine
- Morphine
- Diazepam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.