Lefamulin and Erythromycin Interaction
Drug interaction information between Lefamulin and Erythromycin.
Lefamulin and Erythromycin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Lefamulin and Erythromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two drugs can both interfere with the electrical signals that control your heartbeat. Using them at the same time makes a dangerous heart rhythm more likely.
FDA Label Information
Therefore, avoid concomitant use of XENLETA Injection and XENLETA Tablets with such drugs (for example, Class IA and III antiarrhythmics, antipsychotics, erythromycin, moxifloxacin, tricyclic antidepressants).
Lefamulin Also Interacts With
- Moxifloxacin moderate
- Simvastatin minor
- Alprazolam minor
- Diltiazem minor
- Verapamil minor
Erythromycin Also Interacts With
- Eplerenone major
- Pitavastatin major
- Risperidone major
- Sildenafil major
- Lovastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Lefamulin + Erythromycin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Erythromycin has 63 labeled pairs on file vs Lefamulin's 7. In the moderate band specifically: Lefamulin has 2 (also Moxifloxacin); Erythromycin has 6 (also Lovastatin, Midazolam, Pravastatin, Rivaroxaban).
What mechanism field is on file for Lefamulin and Erythromycin?
These two drugs can both interfere with the electrical signals that control your heartbeat. Using them at the same time makes a dangerous heart rhythm more likely.
Erythromycin carries more major-labeled pairs than Lefamulin
SPL source-record counts only. This page's band is moderate · classes on file: Lefamulin (Pleuromutilin Antibiotic); Erythromycin (Macrolide Antibiotic).
Erythromycin has 4 major-labeled pairs vs Lefamulin's 0. This page itself is in the moderate band, not the major band.
4 major · 6 moderate · 53 minor · 63 total
- Other moderate peers for Erythromycin
- Lovastatin
- Midazolam
- Pravastatin
- Rivaroxaban
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.