Hydromorphone and Phenelzine Interaction
Drug interaction information between Hydromorphone and Phenelzine.
Hydromorphone and Phenelzine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Hydromorphone and Phenelzine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This medicine is an MAO inhibitor that can cause a severe reaction by changing how your body processes serotonin.
FDA Label Information
Examples: Phenelzine, tranylcypromine, and linezolid.
Hydromorphone Also Interacts With
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
- Mirtazapine minor
- Linezolid minor
Phenelzine Also Interacts With
- Sertraline moderate
- Fluoxetine moderate
- Citalopram moderate
- Venlafaxine moderate
- Fluvoxamine moderate
Frequently Asked Questions
What SPL severity band is on file for Hydromorphone + Phenelzine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Phenelzine has 27 labeled pairs on file vs Hydromorphone's 13. In the minor band specifically: Hydromorphone has 13 (also Trazodone, Tramadol, Cyclobenzaprine, Mirtazapine); Phenelzine has 16 (also Acetaminophen/Oxycodone, Buprenorphine, Buprenorphine/Naloxone, Buprenorphine).
What mechanism field is on file for Hydromorphone and Phenelzine?
This medicine is an MAO inhibitor that can cause a severe reaction by changing how your body processes serotonin.
Phenelzine's labeled portfolio outnumbers Hydromorphone
SPL source-record counts only. This page's band is minor · classes on file: Hydromorphone (Opioid Analgesic); Phenelzine (Monoamine Oxidase Inhibitor (MAOI)).
0 major · 0 moderate · 13 minor · 13 total
- Other minor peers for Hydromorphone
- Trazodone
- Tramadol
- Cyclobenzaprine
- Mirtazapine
0 major · 11 moderate · 16 minor · 27 total
- Other minor peers for Phenelzine
- Acetaminophen/Oxycodone
- Buprenorphine
- Buprenorphine/Naloxone
- Buprenorphine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.